Table 4

Associations*† (β (95% CI)) of FEV1/FVC ratio at age 7 with childhood concentrations of dialkyl phosphate (DAP) metabolites‡ measured at follow-up visits between 0.5 and 5 years of age

nDEsp ValueDMsp ValueTotal DAPsp Value
Highest FEV1/FVC ratio for children who had one, two, or three manoeuvres
2030.00 (−0.02 to 0.01)0.70.01 (−0.01 to 0.02)0.60.00 (−0.02 to 0.02)0.8
Highest FEV1/FVC ratio for children who had at least two manoeuvres
175−0.01 (−0.03 to 0.01)0.50.01 (−0.01 to 0.03)0.40.01 (−0.02 to 0.03)0.6
  • *Coefficients reflect change per 10-fold increase in creatinine-adjusted (nmol/g creatinine) metabolite concentrations assessed by the area under the curve.

  • †Adjusted for child's sex, age, age squared, log height, maternal smoking during pregnancy, season of birth (mould/wet/pollen/dry), mean daily PM2.5 during first 3 months of life, breast feeding duration, signs of moderate/extensive mould at home visit (6 or 12 months), distance (≤150 m) from highway (6 or 12 months), pets at home (5–7 years), household food insecurity score (7 years), maternal education, season of spirometry and technician.

  • ‡Diethyl (DE) phosphate, dimethyl (DM) phosphate and total dialkyl phosphate (DAP) metabolites.