No prior LABD treatment | Prior LABD treatment | |||||||||||||
All | ||||||||||||||
T+O | T | T+O | T | |||||||||||
Baseline characteristics | ||||||||||||||
n | 426 | 454 | 603 | 579 | ||||||||||
Age (years), mean ± SD | 62.7 ± 8.3 | 62.6 ± 8.8 | 64.6 ± 8.3 | 64.8 ± 8.2 | ||||||||||
Male, n (%) | 291 (68.3) | 338 (74.4) | 442 (73.3) | 417 (72.0) | ||||||||||
Ex-smoker, n (%) | 241 (56.6) | 278 (61.2) | 388 (64.3) | 385 (66.5) | ||||||||||
Post-bronchodilator FEV1 (L), mean ± SD | 1.38 ± 0.52 | 1.43 ± 0.54 | 1.32 (0.50) | 1.32 (0.51) | ||||||||||
Post-bronchodilator FEV1 (% predicted), mean ± SD | 50.7 ± 16.0 | 50.8 ± 15.7 | 48.3 ± 14.7 | 48.8 ± 15.6 | ||||||||||
Reversibility (mL), mean ± SD | 158 ± 160 | 166 ± 144 | 169 ± 138 | 174 ± 147 | ||||||||||
Lung function after 24 weeks of treatment | ||||||||||||||
Adjusted mean FEV1 AUC0–3, (mL) ± SE | 270 ± 1 | 154 ± 9 | 256 ± 8 | 150 ± 8 | ||||||||||
Adjusted mean trough FEV1 (mL) ± SE | 148 ± 1 | 72 ± 1 | 134 ± 8 | 86 ± 8 | ||||||||||
GOLD 2 | ||||||||||||||
T+O | T | T+O | T | |||||||||||
Baseline characteristics | ||||||||||||||
n | 228 | 240 | 274 | 277 | ||||||||||
Age (years), mean ± SD | 63.0 ± 8.2 | 62.5 ± 8.9 | 65.3 ± 8.9 | 64.8 ± 8.7 | ||||||||||
Male, n (%) | 148 (64.9) | 160 (66.7) | 202 (73.7) | 180 (65.0) | ||||||||||
Ex-smoker, n (%) | 117 (51.3) | 128 (53.3) | 176 (64.2) | 179 (64.6) | ||||||||||
Post-bronchodilator FEV1 (L), mean ± SD | 1.72 ± 0.44 | 1.77 (0.47) | 1.69 (0.44) | 1.69 (0.45) | ||||||||||
Post-bronchodilator FEV1 (% predicted), mean ± SD | 63.2 ± 8.8 | 63.1 ± 8.4 | 62.0 ± 7.4 | 62.7 ± 8.1 | ||||||||||
Reversibility (mL), mean ± SD | 175 ± 156 | 184 ± 163 | 201 ± 151 | 196 ± 170 | ||||||||||
Lung function after 24 weeks of treatment | ||||||||||||||
Adjusted mean FEV1 AUC0–3, (mL) ± SE | 289 ± 13 | 175 ± 13 | 302 ± (12) | 179 ± 12 | ||||||||||
Adjusted mean trough FEV1 (mL) ± SE | 146 ± 14 | 68 ± 14 | 156 ± 13 | 95 ± 13 |
SD, standard deviation; SE, standard error.