Cumulative effect of number of risk variants CHI3L1 rs4950928, MMP9 rs17576, MMP9 rs6073983, MMP12 rs652438 on asthma exacerbations
| Combined analysis | |||||||
| Number of risk variants | |||||||
| 0 (n = 41) | 1 (n = 144) | 2 (n = 894) | 3 (n = 1453) | 4 (n = 137) | Odds ratio (95% CI) | p-value | |
| Hospital admission | 3 (8) | 15 (10) | 102 (12) | 197 (14) | 17 (13) | 1.18 (1.00–1.39) | 0.046 |
| OR | 1.18 | 1.39 | 1.64 | 1.94 | |||
| Oral steroid intake | 7 (18) | 28 (19) | 195 (22) | 348 (24) | 41 (30) | 1.19 (1.05–1.36) | 0.008 |
| OR | 1.19 | 1.42 | 1.69 | 2.01 | |||
Count (%), odds ratio (95% confidence intervals), p values calculated by binary logistic regression adjusted for age, sex and study membership.