Prevalence rates of potential systemic corticosteroid-induced comorbidity and comparisons by groups in the OPCRD dataset
| Morbidity | Severe asthma (%) (n=808) | Mild/moderate asthma (%) (n=3975) | OR (95% CI)* | p Value* | Non-asthma controls (%) (n=2412) | OR (95% CI)* | p Value* |
|---|---|---|---|---|---|---|---|
| Type II diabetes | 82 (10) | 281 (7) | 1.46 (1.11 to 1.91) | 0.006 | 149 (6) | 1.76 (1.30 to 2.38) | <0.001 |
| Obesity (BMI >30 kg/m2) | 339 (42) | 1385 (35) | 1.36 (1.16 to 1.59) | <0.001 | 561 (23) | 2.04 (1.74 to 2.39) | <0.001 |
| Osteopenia | 78 (10) | 85 (2) | 5.26 (3.75 to 7.37) | <0.001 | 41 (2) | 6.68 (4.28 to 10.43) | <0.001 |
| Osteoporosis | 126 (16) | 162 (4) | 5.23 (3.97 to 6.89) | <0.001 | 74 (3) | 6.53 (4.63 to 9.21) | <0.001 |
| Fracture | 41 (5) | 134 (3) | 1.54 (1.06 to 2.22) | 0.022 | 88 (4) | 1.65 (1.14 to 2.39) | 0.007 |
| Dyspeptic disorders | 524 (65) | 1331 (34) | 3.99 (3.37 to 4.72) | <0.001 | 578 (24) | 4.88 (4.11 to 5.79) | <0.001 |
| Glaucoma | 32 (4) | 137 (3) | 1.12 (0.75 to 1.68) | 0.58 | 67 (3) | 1.41 (0.89 to 2.25) | 0.15 |
| Cataract | 70 (9) | 195 (5) | 1.89 (1.39 to 2.56) | <0.001 | 105 (4) | 2.42 (1.70 to 3.43) | <0.001 |
| Cardiovascular disease | 77 (10) | 277 (7) | 1.36 (1.02 to 1.81) | 0.035 | 168 (7) | 1.57 (1.14 to 2.15) | 0.005 |
| Hypertension | 276 (34) | 1145 (29) | 1.35 (1.12 to 1.61) | 0.001 | 596 (25) | 1.76 (1.44 to 2.14) | <0.001 |
| Psychiatric conditions/anxiety/depression | 310 (38) | 1238 (31) | 1.43 (1.22 to 1.69) | <0.001 | 607 (25) | 1.67 (1.42 to 1.97) | <0.001 |
| Hypercholesterolaemia | 124 (15) | 561 (14) | 1.15 (0.92 to 1.44) | 0.21 | 258 (11) | 1.61 (1.25 to 2.08) | <0.001 |
| Sleep disorder | 33 (4) | 99 (2.5) | 1.70 (1.13 to 2.53) | 0.010 | 40 (2) | 2.21 (1.46 to 3.35) | <0.001 |
| Chronic kidney disease | 110 (14) | 342 (9) | 1.80 (1.39 to 2.32) | <0.001 | 167 (7) | 2.41 (1.81 to 3.21) | <0.001 |
*OR (95% CI) and p values are calculated for the severe asthma cohort relative to each of the other two groups.
BMI, body mass index; OPCRD, Optimum Patient Care Research Database.