Table 3

Treatment modalities of lung cancers diagnosed in the Teesside and Varese 2000 cohort7 and 2010 cohort

 TeessideVarese
2000 Cohort2010 Cohortp Value2000 Cohort2010 Cohortp Value
Total lung cancer cases, n261*324243260
Treatment
 No active cancer treatment130 (50%)110 (34%)<0.00160 (25%)64 (25%)1
 Radical radiotherapy (≥50 Gy)1 (0.4%)24 (7%)<0.0012 (1%)1 (0.5%)0.523
 Palliative radiotherapy66 (25%)48 (15%)0.00154 (22%)27 (10%)<0.001
 Chemotherapy35 (13%)51 (16%)0.42945 (19%)81 (31%)0.001
 Radiotherapy+chemotherapy12 (5%)54 (17%)<0.00123 (9%)23 (9%)0.810
 Other active treatment0 (0%)1 (0%)0.3690 (0%)1 (0.5%)0.333
 Surgical resection†
  In all lung cancers17/261 (7%)36/324 (11%)‡0.05459/243 (24%)63/260 (24%)‡1
   Lobectomy8/17 (47%)27/36 (75%)42/59 (71%)49/63 (78%)
   Pneumonectomy7/17 (41%)6/36 (17%)9/59 (15%)8/63 (13%)
   Wedge resection2/17 (12%)3/36 (8%)8/59 (14%)6/63 (9%)
  In NSCLC17/147 (12%)36§/199 (18%)0.09659/169 (35%)63**/189 (33%)0.753
  In stage I–II NSCLC17/37 (46%)27/40 (67%)††0.05644/53 (83%)43/49 (88%)††0.500
  In stage IIIA NSCLC0/22 (0%)5/47 (11%)‡‡0.276§§8/20 (40%)13/39 (33%)‡‡0.613
  In symptomatic lung cancers13/253 (5%)29/300 (10%)¶¶0.04531/176 (18%)27/196 (14%)¶¶0.308

  • Data are presented as number of patients with percentage of total valid cases.

  • *Treatment data not available in seven untraceable patients.

  • †All surgeries performed with curative intent, including cases undergoing induction chemotherapy or adjuvant chemo/radiotherapy.

  • ‡Resection rate in all lung cancers in Varese versus Teesside: p<0.001.

  • §Including 27 NSCLC stage I–II; 5 NSCLC stage IIIA; 2 NSCLC stage IIIB; 2 NSCLC stage IV.

  • ¶Resection rate in all NSCLC cases in Varese versus Teesside: p<0.001.

  • **Including 43 NSCLC stage I–II; 13 NSCLC stage IIIA; 4 NSCLC stage IIIB; 1 NSCLC stage IV. Stage not available for two patients.

  • ††Resection rate in NSCLC stage I–II in Varese versus Teesside: p=0.020.

  • ‡‡Resection rate in NSCLC stage IIIA in Teesside versus Varese: p=0.010.

  • §§Yates’ p value.

  • ¶¶Resection rate in symptomatic lung cancers in Teesside versus Varese: p=0.205.

  • NSCLC, non-small cell lung cancer.