Summary of exploratory efficacy outcome measures
| Absolute change from KIWI baseline, mean (SD) | KIWI (Wk 24) | KLIMB (Wk 72) |
| Sweat chloride, mmol/L | -46.9 (26.2) P < 0.0001 | -45.4 (31.3) P < 0.0001 |
| Weight, kg | 1.4 (0.6) P < 0.0001 | 3.2 (1.1) P < 0.0001 |
| Weight-for-age z-score | 0.2 (0.3) P < 0.0001 | 0.1 (0.5) P = 0.3 |
| BMI, kg/m2 | 0.3 (0.5) P = 0.002 | -0.2 (0.7) P = 0.2 |
| BMI-for-age z-score | 0.4 (0.4) P < 0.0001 | 0.1 (0.5) = 0.5 |
| Stature, cm | 3.3 (1.2) P < 0.0001 | 10.2 (1.8) P < 0.0001 |
| Stature-for-age z-score | -0.01 (0.3) P = 0.8 | 0.1 (0.3) P = 0.01 |
| Fecal elastase-1, µg/ga | 99.8 (138.4) | 101.9 (152.3) |
| Immunoreactive trypsinogen, ng/mLa | -20.7 (24.0) | -18.9 (28.0) |
↵P values for both KIWI and KLIMB assessed for absolute change from KIWI baseline. aSignificance was not assessed for these changes.