Moderate/severe exacerbations, pneumonia and diabetes mellitus during the outcome period for patients initiating on FP/SAL at 500 mcg/day andmcg/day via MDI versus DPI
| Initiating at 500 mcg/day FP/SAL N = 472 (100%) | Initiating at 1000 mcg/day FP/SAL N = 1172 (100%) | ||||
| MDI N = 236 (100%) | DPI N = 236 (100%) | MDI N = 586 (100%) | DPI N = 586 (100%) | ||
| Number of all moderate/severe COPD exacerbations | 0, n (%) | 137 (58.1) | 121 (51.3) | 299 (51) | 317 (54.1) |
| 1, n (%) | 56 (23.7) | 59 (25.0) | 152 (25.9) | 149 (25.4) | |
| 2–3, n (%) | 35 (14.8) | 35 (14.8) | 100 (17.1) | 87 (14.8) | |
| 4+, n (%) | 8 (3.4) | 21 (8.9) | 35 (6.0) | 33 (5.6) | |
| Rate ratio (95% CI) | 0.72 (0.55, 0.95) | 1 | 1.10 (0.93, 1.30) | 1 | |
| Adjusted rate ratio (95% CI) | 0.71 (0.54, 0.93) | 1 | 1.11 (0.94, 1.30) | 1 | |
| Pneumonia | No, n (%) | 231 (97.9) | 232 (98.3) | 582 (99.3) | 583 (99.5) |
| Yes, n (%) | 5 (2.1) | 4 (1.7) | 4 (0.7) | 3 (0.5) | |
| Odds ratio (95% CI) | 1.25 (0.33, 4.76) | 1 | 1.33 (0.30, 5.88) | 1 | |
| Diabetes mellitus | No, n (%) | 214 (90.7) | 211 (89.4) | 493 (84.1) | 497 (84.8) |
| Yes, n (%) | 22 (9.3) | 25 (10.6) | 93 (15.9) | 89 (15.2) | |
| Odds ratio (95% CI) | 0.87 (0.59, 1.43) | 1 | 1.05 (0.80, 1.39) | 1 | |
| Adjusted odds ratio (95% CI) | 0.88 (0.40, 1.92) | 1 | 1.10 (0.71, 1.69) | 1 | |