Univariable (left column) and multivariable (right column) linear regression analysis of the predictors of intestinal permeability (L/M ratio) and endotoxemia in the whole NAFLD population (n=80)
| Univariable | Multivariable | |||
|---|---|---|---|---|
| Parameter | β (SE (β)) | p Value | β (SE (β)) | p Value |
| L/M ratio | ||||
| SaO2 <90% (%TST) | 0.410 (0.111) | 0.002 | 0.396 (0.180) | 0.026 |
| ETpCO2 (mm Hg) | 0.208 (0.131) | 0.031 | – | – |
| Systolic BP (mm Hg) | 0.196 (0.171) | 0.038 | – | – |
| Plasma LPS (EU/mL) | 0.269 (0.211) | 0.029 | – | – |
| AHI (events/h) | 0.297 (0.124) | 0.023 | – | – |
| Plasma LPS | ||||
| SaO2 <90% (%TST) | 0.692 (0.107) | <0.001 | 0.358 (0.107) | 0.008 |
| BMI z-score | 0.359 (0.101) | 0.003 | 0.266 (0.108 | 0.019 |
| L/M ratio | 0.418 (0.119) | 0.001 | 0.366 (0.123) | 0.006 |
| Plasma adiponectin (ng/mL) | −0.356 (0.134) | 0.009 | – | – |
| AHI (events/h) | 0.268 (0.189) | 0.027 | – | – |
| Nadir SaO2 (%TST) | −0.219 (0.121) | 0.032 | – | – |
Only statistically significant associations are shown. Skewed variables were log-transformed.
AHI, apnoea/hypopnoea index; BMI, body mass index; BP, blood pressure; ETpCO2, mean end-tidal pCO2; L/M ratio, lactulose/mannitol ratio; LPS, lipopolysaccharide; NAFLD, non-alcoholic fatty liver disease; SaO2 <90%, total duration of haemoglobin desaturation, expressed as %TST