Table 7

Univariable (left column) and multivariable (right column) linear regression analysis of the predictors of intestinal permeability (L/M ratio) and endotoxemia in the whole NAFLD population (n=80)

Parameterβ (SE (β))p Valueβ (SE (β))p Value
L/M ratio
 SaO2 <90% (%TST)0.410 (0.111)0.0020.396 (0.180)0.026
 ETpCO2 (mm Hg)0.208 (0.131)0.031
 Systolic BP (mm Hg)0.196 (0.171)0.038
 Plasma LPS (EU/mL)0.269 (0.211)0.029
 AHI (events/h)0.297 (0.124)0.023
Plasma LPS
 SaO2 <90% (%TST)0.692 (0.107)<0.0010.358 (0.107)0.008
 BMI z-score0.359 (0.101)0.0030.266 (0.1080.019
 L/M ratio0.418 (0.119)0.0010.366 (0.123)0.006
 Plasma adiponectin (ng/mL)−0.356 (0.134)0.009
 AHI (events/h)0.268 (0.189)0.027
 Nadir SaO2 (%TST)−0.219 (0.121)0.032
  • Only statistically significant associations are shown. Skewed variables were log-transformed.

  • AHI, apnoea/hypopnoea index; BMI, body mass index; BP, blood pressure; ETpCO2, mean end-tidal pCO2; L/M ratio, lactulose/mannitol ratio; LPS, lipopolysaccharide; NAFLD, non-alcoholic fatty liver disease; SaO2 <90%, total duration of haemoglobin desaturation, expressed as %TST