Presence of ATS/IDSA 2007 minor criteria and additional suggested predictive parameters according to emergency status within 72 h (after exclusion of all patients presenting with major criteria)
| Criteria | Emergency 72 h without immediate MV/VS (N=45) | Non-emergency (N=3287) | Univariate p value | Multivariate HR (Cox) (95% CI) | Multivariate p value (Cox) |
|---|---|---|---|---|---|
| ATS/IDSA minor criteria, N/N with data (%) | |||||
| PaO2/FiO2 ratio ≤250 | 17/45 (38) | 660/3287 (20) | 0.003 | 0.12 | |
| Respiratory rate ≥30 | 7/45 (16) | 305/3287 (9) | 0.15 | 0.11 | |
| Multilobar shadowing | 17/44 (39) | 809/3174 (25) | 0.047 | 0.06 | |
| Confusion | 9/45 (20) | 179/3285 (5) | <0.001 | 2.92 (1.28 to 6.67) | 0.01 |
| Hypotension | 17/45 (38) | 704/3277 (21) | 0.008 | 1.97 (1.04 to 3.74) | 0.036 |
| Urea ≥20 mg/dL | 26/42 (62) | 1005/3060 (33) | <0.001 | 2.62 (1.38 to 5.00) | 0.003 |
| White cell count <4000 cells/mm3 | 0/45 (0) | 42/3281 (1) | 0.45 | 0.42 | |
| Platelets <100 000 cells/mm3 | 2/44 (5) | 59/3258 (2) | 0.18 | 0.42 | |
| Hypothermia <36°C | 2/45 (4) | 39/3273 (1) | 0.05 | 0.11 | |
| Additional criteria, N/N with data (%) | |||||
| pH <7.35 | 5/36 (14) | 76/2386 (3) | <0.001 | 3.26 (1.12 to 9.48) | 0.03 |
| Sodium <130 mmol/L | 4/43 (9) | 225/3259 (7) | 0.54 | 0.78 | |
| Glucose <4.4 mmol/L | 3/43 (7) | 75/3116 (2) | 0.06 | 0.26 | |
| Glucose >14 mmol/L | 2/43 (5) | 113/3116 (4) | 0.72 | 0.57 | |
Significant p values are shown in bold.
ATS, American Thoracic Society; IDSA, Infectious Disease Society of America; MV/VS, mechanical ventilation and/or vasopressor support.