Outcome measure data: outcome data for completed (fully or partially) measures have been presented
| Fast track | Waiting list | Effect size (95% CI) at 4 weeks | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline (mean (SD) or n (%) | 4 weeks (mean (SD) or n (%) | Change score Mean (SD) | 8 week (mean (SD) or n (%) | Baseline (mean (SD) or n (%) | 4 weeks (mean (SD) or n (%) | Change score Mean (SD) | 8 week (mean (SD) or n (%) | ||
| Primary end point | N=26 | N=23 | N=27 | N=24 | |||||
| POS | 16.8 (5.6) | 11.2 (7.9) | −5.7 (7.5) | 17.0 (6.3) | 16.8 (8.9) | −0.4 (8.0) | −0.7 (−1.2 to −0.1) | ||
| The mean change difference between the two arms was −5.3 (95% CI: −9.8 to −0.7) Independent t test p=0.02 | |||||||||
| Secondary outcomes | |||||||||
| Patients | |||||||||
| POS | N=19 | N=15 | |||||||
| 11.2 (7.3) | 12.5 (6.6) | ||||||||
| D12 | N=25* | N=22* | N=19 | N=27 | N=24 | N=15 | |||
| 22.8 (8.7) | 21.6 (10.1) | −0.8 (7.2) | 20.4 (9.8) | 25.9 (8.2) | 25.0 (10.7) | −0.6 (21.3) | 21.3 (10.5) | −0.3 (−0.9 to 0.3) | |
| KBILD† | N=26 | N=23 | N=19 | N=27 | N=24 | N=15 | |||
| 35.8 (13.0) | 40.0 (16.2) | 3.5 (11.0) | 43.2 (18.4) | 32.3 (12.9) | 30.3 (16.2) | −2.6 (21.3) | 34.9 (18.0) | 0.6 (0.0 to 1.2) | |
| SGRQ | N=25‡ | N=22‡ | N=18‡ | N=26§ | N=24 | N=15 | |||
| Symptoms | 62.2 (17.7) | 62.0 (20.5) | 1.4 (16.5) | 52 (20.1) | 66.3 (24.5) | 65.8 (23.0) | −2.0 (23.7) | 60.2 (23.8) | −0.2 (−0.8 to 0.4) |
| Activity | 88.9 (9.7) | 85.3 (17.6) | −3.1 (13.6) | 87.1 (10.7) | 93.7 (5.0) | 92.4 (7.8) | −1.6 (6.8) | 91.4 (5.2) | −0.5 (−1.1 to 0.1) |
| Impact | 61.6 (18.0) | 56.3 (20.3) | −4.0 (19.7) | 57.4 (20.8) | 71.4 (12.8) | 74.8 (14.9) | 2.8 (13.3) | 62.3 (13.5) | −1.0 (−1.6 to −0.4) |
| Total | 70.0 (13.0) | 66.0 (16.4) | −2.8(14.9) | 65.7 (14.7) | 76.8 (10.1) | 78.6 (11.8) | 0.7 (10.5) | 70.8 (10.8) | −0.9 (−1.5 to −0.3) |
| MRC | N=26 | N=23 | N=19 | N=27 | N=24 | N=15 | |||
| Median | 4 | 4 | 4 | 5 | 5 | 4 | |||
| IQR (25–75) | 4–5 | 4–5 | 4–5 | 4–5 | 4–5 | 4–5 | |||
| HADs | N=26 | N=23 | N=19 | N=27 | N=24 | N=15 | |||
| Anxiety | 9.6 (4.6) | 8.1 (4.1) | −1.7 (3.3) | 7.1 (4.6) | 9.7 (5.7) | 10.8 (5.5) | 1.2 (4.8) | 7.9 (5.5) | −0.6 (−1.1 to 0.0) |
| Depression | 9.0 (3.1) | 9.4 (3.0) | 0.3 (3.2) | 8.3 (3.7) | 11.0 (4.7) | 12.3 (4.8) | 1.5 (4.12) | 9.3 (4.5) | −0.7 (−1.3 to −0.1) |
| Total score | 18.6 (6.4) | 17.5 (6.3) | −1.4 (5.0) | 15.4 (7.7) | 20.7 (9.0) | 23.0 (9.7) | 2.8 (8.1) | 17.2 (9.4) | −0.7 (−1.2 to −0.1) |
| Carers | |||||||||
| POS | N=19 | N=15 | N=13 | N=26 | N=22 | N=15 | |||
| 17.8 (6.5) | 14.7 (6.5) | −2.9 (5.8) | 16.1 (6.9) | 18.5 (6.2) | 18.0 (8.4) | −0.7 (9.6) | 13.7 (6.3) | −0.4 (−1.1 to 0.2) | |
| ZBI | N=19 | N=16 | N=13 | N=26 | N=23 | N=16 | |||
| 22.2 (15.2) | 22.3 (15.3) | 0.1 (0.2) | 26.2 (13.4) | 32.2 (11.7) | 31.7 (17.3) | −0.1(0.3) | 25.4 (13.4) | −0.6 (−1.2 to 0.1) | |
| HADs | N=19 | N=16 | N=13 | N=26 | N=23 | N=16 | |||
| Anxiety | 9.3 (4.3) | 8.8 (4.8) | −0.5 (4.8) | 9.2 (3.7) | 11.0 (5.9) | 11.7 (5.6) | 0.6 (5.3) | 9.8 (4.6) | −0.6 (−1.2 to 0.1) |
| Depression | 7.0 (4.9) | 6.4 (4.1) | −0.3 (3.5) | 7.0 (4.2) | 8.7 (5.0) | 9.6 (4.9) | 1.0 (4.6) | 7.2 (3.9) | −0.7 (−1.3 to 0.0) |
| Total score | 16.3 (8.7) | 15.2 (8.3) | −0.8 (8.0) | 16.2 (7.4) | 19.7 (10.4) | 21.3 (9.9) | 1.7 (8.7) | 17.0 (8.2) | −0.7 (−1.3 to 0.0) |
| CQLC† | N=18 | N=15 | N=13 | N=25 | N=21 | N=13 | |||
| Burden | 21.9 (8.3) | 21.5 (7.1) | −0.6 (6.9) | 20.2 (5.7) | 25.2 (8.3) | 25.2 (8.5) | −0.2 (8.0) | 22.1 (9.2) | −0.5 (−1.1 to 0.2) |
| Disruptiveness | 7.8 (6.0) | 7.1 (6.9) | −0.6 (4.3) | 7.7 (4.8) | 9.6 (5.4) | 9.3 (5.5) | 0.0 (4.9) | 7.6 (5.9) | −0.4 (−1.0 to 0.3) |
| Adaptation | 15.6 (5.1) | 15.8 (6.1) | 0.5 (4.3) | 15.9 (5.4) | 14.7 (6.8) | 14.4 (5.7) | 0.1 (5.3) | 16.8 (4.2) | 0.2 (−0.4 to 0.9) |
| Financial | 2.8 (3.0) | 2.5 (3.0) | −0.4 (2.1) | 2.4 (3.6) | 2.7 (2.9) | 2.7 (2.8) | 0.3 (2.5) | 2.3 (2.1) | −0.1 (−0.7 to 0.6) |
| Total score | 60.8 (17.4) | 58.5 (15.3) | −2.5 (11.0) | 58.3 (15.6) | 66.7 (16.3) | 66.3 (18.4) | 0.7 (15.2) | 60.2 (23.9) | −0.4 (−1.1 to 0.2) |
All analyses conducted by originally assigned groups.
Lower scores on the SGRQ and higher scores on the KBILD indicate a better quality of life.
*One patient had >three items missing on the D12 questionnaire and was therefore excluded as per author's instructions.
†Increase in scores indicates improvement.
‡One patient completed McGill quality of life not SGRQ.
§One patient removed as >six items missing on activity SGRQ.
CQLC, carer quality of life cancer; HADs, Hospital Anxiety and Depression Scale; KBILD, King's Brief Interstitial Lung Disease questionnaire; MRC, Medical Research Council Scale; POS, Palliative Care Outcome Scale; SGRQ, St George's Respiratory Questionnaire; ZBI, Zarit Burden Inventory.