Table 2

Results from the comprehensive respiratory assessment over the first 18 months

Exercise/symptom domainExacerbation domain
RV/TLC (%)64 (11)COPD-related admissions0.9 (1.4)
RV (% predicted)213 (27)Antibiotics courses5.1 (4.4)
Hyperinflation*59%Oral steroid courses5.0 (4.4)
TLCO (% predicted)38Blood eosinophilia†33%
ISWT (m)140Sputum culture positive38%
QMVC (% predicted)45 (24)Flu vaccination94%
MRC dyspnoea score4 (IQR 4–4)Pneumonia vaccine84%
Previous PR attendance71%Maintenance oral steroids11%
Exercise desaturation‡51%Maintenance antibiotics21%
CAT score25.5 (6.3)
Comorbidity domainPrognostic indicator domain
Other comorbidity76%Pack years (years)39 (16)
Abnormal BNP§22%Current smokers25%
Framingham risk scoreLong-term oxygen therapy35%
Low (<10%)46%‘Surprise’ question (% no)23%
Intermediate (11–20%)36%BMI <21 kg/m232%
High (>20)18%Nutritional depletion¶53%
Sarcopenia**64%iBODE††7.3 (1.1)
BMI (kg/m2)25.3 (7.4)
BMI ≥30 kg/m225%
HADS anxiety >10§§33%
HADS depression >10§§27%
  • Figures for events refer to the preceding 12 months. Bone mineral and lean mass measured from DEXA. Lung volume measurements measured using body plethysmography (n=71).

  • *Residual volume >150% predicted and RV/TLC >55% (calculated as proportion of total population of 121 subjects).

  • †Blood eosinophil count >0.4×109.

  • ‡≥4% desaturation on exertion.

  • §>95% upper limit of CI.

  • ¶Nutritional depletion: FFMI <15 kg/m2 (women)/<17 kg/m2 (men) or BMI <21 kg/m2 (5).

  • **SMI calculated as the height normalised sum of appendicular lean mass. Sarcopenia defined as SMI <7.23 (men) or <5.67 (women) (5).

  • ††Mean (SD) iBODE score.12

  • ‡‡T score ≤−2.5.

  • §§HADS anxiety or depression scores >10.

  • BMI, body mass index; BNP, brain natriuretic peptide; CAT, COPD assessment test; DEXA, dual emission X-ray absorptiometry; FFMI, fat-free mass index; HADS, hospital anxiety and depression score; iBODE, Body mass index, airflow Obstruction, Dyspnoea, and Exercise; ISWT, incremental shuttle walking test; MRC, Medical Research Council; PR, pulmonary rehabilitation; QMVC, reduced maximum voluntary quadriceps contraction strength; RV, residual volume; SRS, skeletal muscle index; TLC, total lung capacity; TLCO, transfer factor of the lung for carbon monoxide.