ROC characteristics and prognostic properties of minor criteria for emergency CAP within 72 h presenting without immediate need of MV/VS
| Criteria | AUC (95% CI) | Cut-off point | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | +LR (95% CI) | −LR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| ATS/IDSA minor criteria 1–9 | 0.72 (0.71 to 0.74) | 1 | 93 (80 to 98) | 31 (29 to 33) | 1.8 (1.3 to 2.5) | 99.7 (99 to 100) | 1.34 (1.2 to 1.5) | 0.24 (0.08 to 0.27) |
| 2 | 68 (51 to 81) | 66 (65 to 68) | 2.7 (1.8 to 3.9) | 99.3 (98 to 100) | 2.01 (1.6 to 2.5) | 0.49 (0.3 to 0.8) | ||
| ATS/IDSA minor criteria 1–6 | 0.73 (0.71 to 0.74) | 1 | 93 (80 to 99) | 32 (30 to 33) | 1.8 (1.3 to 2.5) | 99.7 (99 to 100) | 1.35 (1.2 to 1.5) | 0.23 (0.08 to 0.7) |
| 2 | 66 (49 to 80) | 68 (66 to 69) | 2.8 (1.8 to 4) | 99.3 (99 to 100) | 2.04 (1.6 to 2.6) | 0.5 (0.3 to 0.8) | ||
| ATS/IDSA minor criteria 1–6 and pH | 0.73 (0.71 to 0.74) | 1 | 94 (79 to 99) | 28 (26 to 30) | 1.9 (1.3 to 2.7) | 99.7 (99 to 100) | 1.3 (1.2 to 1.4) | 0.22 (0.06 to 0.9) |
| 2 | 69 (50 to 84) | 63 (61 to 65) | 2.7 (1.7 to 4) | 99.3 (99 to 100) | 1.86 (1.5 to 2.4) | 0.5 (0.3 to 0.8) |
Bold values show the optimal cut-off point according to the Youden Index.
N Minor criteria 1–9: 3049; N minor criteria 1–6: 3084; N minor criteria 1–6+ pH: 2268.
ATS, American Thoracic Society; AUC, area under the curve; CAP, community-acquired pneumonia; IDSA, Infectious Disease Society of America; LR, likelihood ratio; MV/VS, mechanical ventilation and/or vasopressor support; NPV, negative predictive ratio; PPV, positive predictive ratio; ROC, receiver operating characteristic.