Doses of medication to be used and anticipated time to assess if there has been a clinical response
chILD ventilated or close to ventilation | chILD not ventilated or close to ventilation | |
---|---|---|
Methylprednisolone | ||
Dose | Intravenous 10 mg/kg or 500 mg/m2 | Intravenous 10 mg/kg or 500 mg/m2 |
Response rate | 7 days | 28 days |
Comment | 30 mg/kg used by some centres | As alternative to oral prednisolone. Use before other therapies and judge response |
Prednisolone | ||
Dose | Oral 1 mg/kg, used in between pulses of methylprednisolone | Oral 2 mg/kg, as alternative to methylprednisolone pulses. Use before other therapies and judge response |
Response rate | 7 days | 28 days |
Hydroxychloroquine | ||
Dose | 10 mg/kg | 10 mg/kg |
Response rate | 21–28 days | 3 months |
Comment | In children <6 years 6.5 mg/kg in some centres to reduce toxicity | In children <6 years 6.5 mg/kg in some centres to reduce toxicity. No preference over azithromycin as second line. 54% would consider Hydroxychloroquine as sole therapy in mild stable chILD |
Azithromycin | ||
Dose | 10 mg/kg 3 days per week | 10 mg/kg 3 days per week |
Response rate | 3 months | 3 months. |
Comment | No preference over hydroxychloroquine as second line. 51% would consider azithromycin as sole therapy in mild stable chILD |
Results are simple majority assessed by median?/mean?.
chILD, childhood interstitial lung disease; IV, intravenous; PIG, pulmonary interstitial glycogenosis.