SGRQ total score | ||||
---|---|---|---|---|
Whole group (n=1832) | Improvement (Δ≤−4 points) (n=675) | No change (Δ=−3.99 to 3.99) (n=630) | Deterioration (Δ≥4 points) (n=527) | |
Age, years | 63.4 (7.0) | 63.0 (7.0) | 63.6 (7.1) | 63.6 (6.9) |
Male, n (%) | 1199 (65.4) | 438 (64.9) | 411 (65.2) | 350 (66.4) |
Current smokers, n (%) | 659 (36.0) | 258 (38.2)* | 202 (32.1)** | 199 (37.8) |
BMI, kg/m2† | 26.0 (22.7–29.6) | 25.9 (22.9–29.3) | 26.5 (23.2–29.9)** | 25.6 (22.1–29.6) |
FEV1, % predicteda,b | 48.7 (15.6) | 48.8 (15.2) | 49.3 (15.9) | 47.7 (15.7) |
FEV1, La,b | 1.4 (0.5) | 1.4 (0.5) | 1.4 (0.6) | 1.3 (0.5) |
FVC, La,b | 3.1 (0.9) | 3.1 (0.9) | 3.1 (0.9) | 3.0 (0.9) |
FEV1/FVC (%)a,b | 44.9 (11.5) | 44.9 (11.4) | 45.6 (11.8) | 44.1 (11.4) |
Exacerbations previous 12 months, n† | 0.9 (1.2) | 0.8 (1.2) | 0.9 (1.3) | 0.9 (1.2) |
6MWD, mc,d,e | 378 (119) | 382 (112) | 378 (127) | 371 (118) |
mMRC dyspnoea score (%)f,g,h,i | 1.6 (1.1) | 1.7 (1.0) | 1.7 (1.1) | 1.6 (1.1) |
BODE index, pointsj,k,l,m | 3.1 (2.1) | 3.0 (1.9) | 3.1 (2.2) | 3.2 (2.1) |
CES-D score, pointsn,o,p,q | 11.2 (9.3) | 11.7 (9.3) | 10.9 (9.2) | 10.7 (9.3) |
FACIT score, pointsi,h,r | 35.4 (10.6) | 34.8 (10.5) | 35.6 (11.0) | 36.0 (10.3) |
SGRQ symptom score, points | 60.1 (21.5) | 64.1 (20.4)*,** | 58.5 (21.9) | 56.7 (21.5) |
SGRQ activity score, points | 61.8 (21.9) | 65.5 (19.6)*,** | 60.3 (23.7) | 58.8 (21.8) |
SGRQ impact score, points | 35.5 (19.3) | 40.0 (18.8)*,** | 34.7 (20.3)** | 30.9 (17.4) |
SGRQ total score, points | 47.6 (18.3) | 51.8 (16.9)*,** | 46.4 (19.7)** | 43.6 (17.1) |
One-year change SGRQ total score, points | −1.3 (10.7) | −11.8 (7.5)*,** | 0.3 (2.3)** | 10.7 (5.9) |
Values expressed as mean (SD), median (25–75% percentile) or number of patients (n), proportion (%).
*p≤0.05 versus ‘No change’; **p≤0.05 versus ‘Deterioration’.
†Non-parametric tests were used for skewed data.
an=1828 (‘whole group’), bn=671 (‘improvement’), cn=1791 (‘whole group’), dn=617 (‘no change’), en=512 (‘deterioration’), fn=1787 (whole group’), gn=658 (‘improvement’), hn=611 (‘no change’), in=518 (‘deterioration’), jn=1743 (‘whole group’), kn=641 (‘improvement’), ln=667 (‘no change’), mn=504 (‘deterioration’), nn=1801 (‘whole group’), on=598 (‘improvement’), pn=614 (‘no change’), qn=520 (‘deterioration’), rn=665 (‘improvement’).
BMI, body mass index; FACIT, Functional Assessment of Chronic Illness Therapy fatigue scale; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; 6MWD, 6-min walk distance; MRC, Medical Research Council dyspnoea scale; BODE, body mass index, airway obstruction, dyspnoea, and exercise tolerance; CES-D, Center for Epidemiologic Studies Depression Scale; SGRQ, St George's Respiratory Questionnaire.