Baseline characteristics. Data are mean (SD) unless stated otherwise
| 20 W cohort (n=12) | 15 W cohort (n=10) | p Value | |
|---|---|---|---|
| Age (years) | 62.92 (11.37) | 64.40 (8.87) | 0.740 |
| Male (n, %) | 7 (58) | 4 (40) | 0.669 |
| Ethnic origin (n, %) | |||
| White | 12 (100) | 8 (80) | 0.195 |
| Black | 0 (0) | 2 (20) | – |
| History of smoking (n, %) | 12 (100) | 10 (100) | – |
| Pack-years | 38.57 (19.97) | 44.60 (25.86) | 0.544 |
| Wash-out prebronchodilator FEV1 (L) | 0.90 (0.28) | 0.84 (0.15) | 0.551 |
| Wash-out prebronchodilator FVC (L) | 2.56 (0.59) | 2.45 (0.60) | 0.664 |
| Reversibility peak relative change in FEV1 (%) | 25.95 (7.60) | 19.89 (1.91) | 0.019 |
| Run-in tiotropium trough FEV1 (L) | 1.04 (0.39) | 0.98 (0.23) | 0.651 |
| Run-in tiotropium trough FVC (L) | 2.89 (0.76) | 2.75 (0.60) | 0.661 |
| Cycle endurance time @ 75% of max (min) | 6.71 (3.26) | 4.57 (2.20) | 0.1059 |
| SGRQ-C total score (points) | 56.16 (13.71) | 56.23 (20.85) | 0.9931 |
| Average diameter: right main bronchus (mm)* | 13.42 (1.57) | 13.91 (1.62) | 0.519 |
| Average diameter: left main bronchus (mm)* | 12.02 (1.45) | 12.33 (1.68) | 0.672 |
*Measurements performed by the sponsor using Apollo Software (VIDA Diagnostics, Coralville, Iowa, USA).
FEV1 (L), expiratory volume in 1 s; FVC (L), forced vital capacity (FVC)