ELN | FBLN5 | MFAP4 | LTBP2 | ||||
---|---|---|---|---|---|---|---|
MGI | p Value | MGI | p Value | MGI | p Value | MGI | p Value |
Abnormal tendon morphology | 5.65E-18 | Abnormal aorta elastic tissue morphology | 4.09E-19 | Overexpanded pulmonary alveoli | 8.32E-38 | Osteoarthritis | 1.01E-29 |
Centrally nucleated skeletal muscle fibres | 2.99E-15 | Abnormal aorta wall morphology | 2.73E-18 | Abnormal aorta elastic tissue morphology | 1.70E-36 | Emphysema | 1.43E-24 |
Abnormal cutaneous collagen fibril morphology | 3.94E-15 | Abnormal cutaneous collagen fibril morphology | 5.07E-17 | Abnormal aorta wall morphology | 4.75E-31 | Abnormal aorta elastic tissue morphology | 1.43E-19 |
Myopathy | 1.22E-13 | Abnormal tendon morphology | 7.93E-16 | Loose skin | 2.52E-29 | Abnormal pulmonary elastic fibre morphology | 2.10E-18 |
Abnormal tracheal cartilage morphology | 1.98E-13 | Loose skin | 1.52E-12 | Emphysema | 2.18E-27 | Abnormal tendon morphology | 4.66E-16 |
Abnormal lung vasculature morphology | 1.20E-12 | Abnormal pulmonary artery morphology | 2.81E-10 | Corneal thinning | 8.77E-23 | Dilated respiratory conducting tubes | 2.27E-14 |
Loose skin | 1.23E-11 | Emphysema | 3.21E-10 | Abnormal tendon morphology | 9.54E-23 | Abnormal aorta wall morphology | 6.85E-14 |
Osteoarthritis | 4.73E-11 | Dystrophic muscle | 1.00E-08 | Abnormal cutaneous collagen fibril morphology | 1.31E-22 | Abnormal cutaneous collagen fibril morphology | 1.10E-13 |
Emphysema | 8.53E-11 | Overexpanded pulmonary alveoli | 4.22E-08 | Abnormal blood vessel physiology | 3.84E-16 | Overexpanded pulmonary alveoli | 2.20E-13 |
Dilated respiratory conducting tubes | 1.39E-10 | Increased systemic arterial systolic blood pressure | 7.93E-08 | Dilated respiratory conducting tubes | 1.70E-15 | Abnormal tracheal cartilage morphology | 3.99E-12 |
Dystrophic muscle | 4.73E-10 | Dilated heart atrium | 1.91E-07 | Abnormal lung vasculature morphology | 3.13E-15 | Abnormal lung morphology | 2.58E-11 |
Overexpanded pulmonary alveoli | 1.14E-09 | Abnormal vascular smooth muscle physiology | 3.56E-07 | Impaired lung alveolus development | 1.83E-14 | Impaired wound healing | 5.90E-11 |
Increased variability of skeletal muscle fibre size | 1.29E-09 | Decreased skin tensile strength | 4.88E-07 | Abnormal kidney medulla morphology | 2.20E-14 | Loose skin | 2.01E-10 |
Muscle degeneration | 1.34E-09 | Abnormal artery morphology | 5.82E-07 | Abnormal pulmonary elastic fibre morphology | 5.33E-14 | Brain inflammation | 2.20E-10 |
Abnormal vertebral body morphology | 1.34E-09 | Dilated respiratory conducting tubes | 1.07E-06 | Increased systemic arterial systolic blood pressure | 9.43E-14 | Abnormal joint morphology | 4.30E-10 |
Small thoracic cavity | 1.48E-09 | Skeletal muscle fibre necrosis | 1.74E-06 | Increased type II pneumocyte number | 1.03E-12 | Decreased susceptibility to injury | 6.72E-10 |
Kidney cortex atrophy | 4.83E-09 | Partial perinatal lethality | 2.99E-06 | Small lung | 4.12E-12 | Abnormal pulmonary alveolus morphology | 1.50E-09 |
Pulmonary hypoplasia | 6.17E-09 | Abnormal lung vasculature morphology | 3.12E-06 | Impaired branching involved in ureteric bud morphogenesis | 8.23E-12 | Abnormal involution of the mammary gland | 2.80E-09 |
Abnormal aorta wall morphology | 9.20E-09 | Polyuria | 4.06E-06 | Abnormal lung saccule morphology | 1.71E-11 | Abnormal thoracic cage shape | 3.56E-09 |
Respiratory distress | 9.23E-09 | Renal tubule atrophy | 6.16E-06 | Abnormal artery morphology | 2.40E-11 | Abnormal heart ventricle morphology | 4.21E-09 |
Overlap in mouse knockout phenotypes is indicated in bold.
ELN, elastin; FBLN5, fibulin-5; LTBP2, latent transforming growth factor β binding protein 2; MFAP4, microfibrillar associated protein 4; MGI, mouse genome informatics; TGFβ, transforming growth factor β.