Table 3B

Gene function prediction in mouse knockout phenotypes

ELNFBLN5MFAP4LTBP2
MGIp ValueMGIp ValueMGIp ValueMGIp Value
Abnormal tendon morphology5.65E-18Abnormal aorta elastic tissue morphology4.09E-19Overexpanded pulmonary alveoli8.32E-38Osteoarthritis1.01E-29
Centrally nucleated skeletal muscle fibres2.99E-15Abnormal aorta wall morphology2.73E-18Abnormal aorta elastic tissue morphology1.70E-36Emphysema1.43E-24
Abnormal cutaneous collagen fibril morphology3.94E-15Abnormal cutaneous collagen fibril morphology5.07E-17Abnormal aorta wall morphology4.75E-31Abnormal aorta elastic tissue morphology1.43E-19
Myopathy1.22E-13Abnormal tendon morphology7.93E-16Loose skin2.52E-29Abnormal pulmonary elastic fibre morphology2.10E-18
Abnormal tracheal cartilage morphology1.98E-13Loose skin1.52E-12Emphysema2.18E-27Abnormal tendon morphology4.66E-16
Abnormal lung vasculature morphology1.20E-12Abnormal pulmonary artery morphology2.81E-10Corneal thinning8.77E-23Dilated respiratory conducting tubes2.27E-14
Loose skin1.23E-11Emphysema3.21E-10Abnormal tendon morphology9.54E-23Abnormal aorta wall morphology6.85E-14
Osteoarthritis4.73E-11Dystrophic muscle1.00E-08Abnormal cutaneous collagen fibril morphology1.31E-22Abnormal cutaneous collagen fibril morphology1.10E-13
Emphysema8.53E-11Overexpanded pulmonary alveoli4.22E-08Abnormal blood vessel physiology3.84E-16Overexpanded pulmonary alveoli2.20E-13
Dilated respiratory conducting tubes1.39E-10Increased systemic arterial systolic blood pressure7.93E-08Dilated respiratory conducting tubes1.70E-15Abnormal tracheal cartilage morphology3.99E-12
Dystrophic muscle4.73E-10Dilated heart atrium1.91E-07Abnormal lung vasculature morphology3.13E-15Abnormal lung morphology2.58E-11
Overexpanded pulmonary alveoli1.14E-09Abnormal vascular smooth muscle physiology3.56E-07Impaired lung alveolus development1.83E-14Impaired wound healing5.90E-11
Increased variability of skeletal muscle fibre size1.29E-09Decreased skin tensile strength4.88E-07Abnormal kidney medulla morphology2.20E-14Loose skin2.01E-10
Muscle degeneration1.34E-09Abnormal artery morphology5.82E-07Abnormal pulmonary elastic fibre morphology5.33E-14Brain inflammation2.20E-10
Abnormal vertebral body morphology1.34E-09Dilated respiratory conducting tubes1.07E-06Increased systemic arterial systolic blood pressure9.43E-14Abnormal joint morphology4.30E-10
Small thoracic cavity1.48E-09Skeletal muscle fibre necrosis1.74E-06Increased type II pneumocyte number1.03E-12Decreased susceptibility to injury6.72E-10
Kidney cortex atrophy4.83E-09Partial perinatal lethality2.99E-06Small lung4.12E-12Abnormal pulmonary alveolus morphology1.50E-09
Pulmonary hypoplasia6.17E-09Abnormal lung vasculature morphology3.12E-06Impaired branching involved in ureteric bud morphogenesis8.23E-12Abnormal involution of the mammary gland2.80E-09
Abnormal aorta wall morphology9.20E-09Polyuria4.06E-06Abnormal lung saccule morphology1.71E-11Abnormal thoracic cage shape3.56E-09
Respiratory distress9.23E-09Renal tubule atrophy6.16E-06Abnormal artery morphology2.40E-11Abnormal heart ventricle morphology4.21E-09
  • Overlap in mouse knockout phenotypes is indicated in bold.

  • ELN, elastin; FBLN5, fibulin-5; LTBP2, latent transforming growth factor β binding protein 2; MFAP4, microfibrillar associated protein 4; MGI, mouse genome informatics; TGFβ, transforming growth factor β.