Patient groups and number of positive results for each biomarker as a percentage of the total in the group
| Investigation | IGRA and test positive (% of group) | |||
|---|---|---|---|---|
| Smear- positive TB | Smear-negative/ culture-positive TB | Recent contact/IGRA positive | TB considered but firm alternative diagnosis reached | |
| IGRA positive | 100 | 100 | 100 | 25 |
| C-reactive protein ( >5 mg/L) | 100 | 90 | 33 | 50 |
| Transthyretin (<200 µg/mL) | 100 | 100 | 100 | 92 |
| Serum amyloid A (>80 mg/L) | 100 | 86 | 39 | 66 |
| Neopterin >10 nmol/L | 100 | 100 | 66 | 66 |