Biomarker concentration
| Biomarker | VAP | Non-VAP | p Value | AUROC (95% CI) |
|---|---|---|---|---|
| IL-1β pg/mL | 712 (112–1999) | 29 (3–184) | <0.001 | 0.81 (0.74 to 0.88) |
| IL-8 pg/mL | 7546 (1987–23 050) | 1401 (369–4422) | <0.001 | 0.74 (0.65 to 0.82) |
| MMP-8 ng/mL | 734 (113–2792) | 66 (11–325) | <0.001 | 0.76 (0.68 to 0.84) |
| MMP-9 ng/mL | 6840 (1721–22 221) | 491 (106–3146) | <0.001 | 0.79 (0.71 to 0.86) |
| HNE ng/mL | 3882 (710–11 183) | 349 (96–1473) | <0.001 | 0.78 (0.70 to 0.85) |
BAL fluid biomarker concentrations for VAP and non-VAP groups. Data are expressed as median and IQR.
AUROC, area under the receiver operator characteristic curve; BAL, bronchoalveolar lavage; HNE, human neutrophil elastase; IL, interleukin; MMP, matrix metalloproteinase; VAP, ventilator-acquired pneumonia.