Adjusted incidence rate ratios (IRRs) of lung cancer and COPD as a function of 100 µmol/L (1.68 mg/dL) serum uric acid levels and including an interaction with smoking status
| Lung cancer | COPD | |||||
|---|---|---|---|---|---|---|
| Adjusted IRRs* | (95% CI) | p Value | Adjusted IRRs* | (95% CI) | p Value | |
| Non-smoker | 1.00 | (Reference) | 1.00 | (Reference) | ||
| Ex-smoker | 3.49 | (1.70 to 7.16) | 2.97 | (2.17 to 4.06) | ||
| Light-moderate (1–19 per day) | 19.54 | (8.93 to 42.79) | 12.89 | (9.06 to 18.35) | ||
| Heavy (≥20 per day) | 58.85 | (25.27 to 137.08) | <0.001 | 19.69 | (13.29 to 29.17) | <0.001 |
| Serum uric acid (per 100 µmol/L)† | 1.00 | 0.84 to 1.19 | NS | 1.04 | 0.96 to 1.11 | NS |
| Non-smoker X uric acid | 1.00 | (Reference) | 1.00 | (Reference) | ||
| Ex-smoker X uric acid | 1.04 | (0.86 to 1.26) | 1.01 | (0.93 to 1.10) | ||
| Light-moderate smoker X uric acid | 0.87 | (0.70 to 1.09) | 0.86 | (0.78 to 0.96) | ||
| Heavy smoker X uric acid | 0.72 | (0.56 to 0.92) | <0.001 | 0.85 | (0.76 to 0.95) | <0.001 |
Wald tests were used to calculate p values for categorical variables and interaction terms
*Adjusted for age, sex, social deprivation, year of uric acid test, smoking status, alcohol, height, weight, blood pressure, non-European ethnicity and particle pollution.
†Conversion factor: µmol/L×0.01 681 mg/dL
NS, non-significant.