Table 6

Results at 12 months after bilateral LVR coil treatment for patients classified as heterogeneous and homogeneous emphysema

 Visual CT assessment*Digital CT assessment*
(12 month follow-up group)(12 month follow-up group)
Heterogeneous (n=20)Homogeneous (n=13)p ValueHeterogeneous (n=16)Homogeneous (n=17)p Value
ΔFEV1, L+0.14±0.30+0.08±0.280.585+0.18±0.32+0.05±0.260.220
ΔRV, L−0.69±0.87−0.68±0.460.859−0.75±0.78−0.66±0.720.719
Δ6MWD, m+53.9±65.1+46.0±67.90.739+74.9±67.4+27.9±57.80.049
ΔSGRQ, points−12.9±15.1−7.3±8.70.187−12.4±13.9−9.1±12.90.491
  • Results are given as mean±SD change from baseline. Heterogeneity and homogeneity were assessed by both a visual CT assessment (a 4-point qualitative score of the degree of tissue destruction where a difference of ≤1 point for both lungs was regarded as homogeneous) and a digital CT assessment (where the software calculated the percentage area of destruction at –950 Hounsfield Units; a difference of ≤25% in destruction for both lungs was regarded as homogeneous).

  • 6MWD, 6-min walking distance; FEV1, forced expiratory volume in 1 s; LVR, lung volume reduction; RV, residual volume; SGRQ, St George's Respiratory Questionnaire total score.

  • *p<0.05 for all end-points compared to baseline.