| Adjusted mean of difference in response from placebo (mL) | |||
|---|---|---|---|
| PrimoTinA-asthma® (Week 24) | MezzoTinA-asthma® (Week 24) | GraziaTinA-asthma® (Week 12) | |
| Tiotropium Respimat®5 µga (n = 456) | Tiotropium Respimat®5 µga(n = 517) | Tiotropium Respimat®5 µg(n = 155) | |
| Peak FEV1(0–3h) | 110 (p < 0.0001) | 185 (p < 0.0001) | 128 (p = 0.0005) |
| Trough FEV1 | 93 (p = 0.0058) | 146 (p < 0.0001) | 122 (p = 0.0010) |
| FEV1 AUC(0–3h) | 107 (p < 0.0001) | 182 (p < 0.0001) | 125 (p = 0.0003) |
| Peak FVC(0–3h) | 87 (p = 0.0050) | 95 (p < 0.0001) | 57 (p = 0.1714) |
aPooled data
AUC, area under the curve; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity