Table 4

Pathological characteristics of cases 7–9, 11, 14 and 15 with humidifier disinfectant-associated lung injury

Histological features	Case 7	Case 8_initial	Case 8_2nd	Case 9	Case 11	Case 14	Case 15_initial	Case 15_2^nd
Specimen type	TBLB	Wedge	Explantation	Needle Bx	Wedge	Wedge	Wedge	Explantation
Stage	Early	Late	Late	Early	Early	Early	Early	Late
Pattern of distribution
Anatomic distribution	Centrilobular	Centrilobular	Centrilobular	Centrilobular	Centrilobular	Centrilobular	Centrilobular	Centrilobular
Diffuse vs patchy	Patchy	Patchy	Diffuse	Patchy	Patchy	Patchy	Patchy	Diffuse
Subpleural and peripheral sparing	Present	Present	Present	Present	Present	Present	Present	Present
Temporal homogeneity	Homogeneous	Homogeneous	Homogeneous	Homogeneous	Homogeneous	Homogeneous	Homogeneous	Homogeneous
Pattern of fibrosis
Interstitial fibroblastic proliferation	Present	Present	Present	Present	Present	Present	Present	Present
Collagenous fibrosis	Absent	Absent	Present	Absent	Absent	Absent	Absent	Present
Smooth muscle metaplasia	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Ring fibrosis	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Microscopic honeycomb change	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Alveolar pathology
Hyaline membrane	Present	Present	Absent	Absent	Present	Absent	Present	Present
Alveolar pneumocyte hyperplasia	Present	Present	Present	Absent	Present	Present	Present	Present
Fibrin thrombi in pulmonary arteries	Absent	Absent	Present	Absent	Absent	Absent	Absent	Absent
Alveolar wall expansion	Present	Present	Present	Present	Present	Present	Present	Present
Chronic inflammatory cell infiltration	Present	Present	Present	Present	Present	Present	Present	Present
Intra-alveolar pathology
Intra-alveolar fibrin	Present	Present	Absent	Absent	Present	Absent	Present	Absent
Intra-alveolar macrophage	Present	Present	Present	Present	Present	Present	Present	Present
Intra-alveolar fibroblastic plug	Present	Present	Present	Present	Present	Present	Present	Present
Small airway pathology
Bronchiolar epithelial denudation	Present	Present	Present	Absent	Present	Present	Present	Present
Bronchiolar wall thickening	Present	Present	Present	Present	Present	Present	Present	Present
Peribronchial fibrosis	Absent	Present	Present	Present	Present	Present	Present	Present
Peribronchial inflammatory cell infiltration	Present	Present	Present	Present	Present	Present	Present	Present
Intraluminal fibroblastic growth (mural fibrosis)	Present	Present	Present	Present	Present	Present	Present	Present
Necrotising injury	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Peribronchial lymphoid follicles	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Others
Giant cell or epithelioid histiocytes	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent
Granuloma	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent