Table 4

Changes in health-related quality-of-life (HRQL) measurements

ITT baselinenCompleters baselinenCompleters 12 monthsnChange over 1 yearn
CCQ-Total
 NIV3.37±1.2963.4±1.2482.9±1.148−0.5 (−0.2 to −0.8) *48
 Controls3.31±1.06903.2±1.0512.8±1.151−0.5 (−0.8 to −0.1) *51
Treatment effect−0.04 (−0.5 to 0.4)
MRF-28-Total
 NIV60.88±23.609958.3±24.35051.0±24.850−7.3 (−12.5 to 2.1) *50
 Controls60.28±23.899055.3±24.25149.4±24.251−5.8 (−10.8 to −0.8)*51
Treatment effect−1.5 (−8.6 to 5.7)
CRQ-Total
 NIV3.47±1.101003.5±1.1504.2±1.2500.7 (0.4 to 1.1)*50
 Controls3.59±1.08893.6±1.1504.4±1.1500.7 (0.5 to 1.0)*50
Treatment effect0.01 (−0.4 to 0.4)
SRI-Total
 NIV48.14±14.9710047.9±15.15055.0±15.4507.0 (3.4 to 10.7)*50
 Controls51.33±15.879053.6±16.95155.8±16.3512.2 (−1.2 to 5.6)51
Treatment effect4.8 (−0.1 to 9.7)
GARS-Total
 NIV36.66±7.5010036.3±9.45034.6± 9.450−1.6 (−3.3 to 0.1)50
 Controls36.76±8.549034.7±8.85132.7±8.251−2.0 (−4.1 to 0.1)51
Treatment effect0.4 (−2.3 to 3.0)
HADS-Total
 NIV15.88±9.249815.6±8.84813.9±8.848−1.7 (−4.0 to 0.6)48
 Controls14.48±8.838713.1±9.15012.7±9.350−0.4 (−2.2 to 1.3)50
Treatment effect−1.3 (−4.1 to 1.6)
MRC
 NIV3.9±1.0983.8±1.0493.4±1.449−0.4 (−0.7 to −0.01)*49
 Controls3.8±1.0903.6±1.1513.3±1.251−0.3 (−0.7 to 0.1)51
Treatment effect−0.05 (−0.6 to 0.5)
  • Data presented as means (±SD) and mean change (95% CIs).

  • Scores represent: CCQ and MRF-28↓=HRQL↑; CRQ and SRI↑=HRQL↑; GARS↓=ADL↑; HADS↓=mood↑; MRC↓=dyspnoea↓.

  • *p<0.05 significant change after 12 months within the group. There was no significant difference in change after 12 months between the groups (treatment effect).

  • CCQ, Clinical COPD Questionnaire; Controls, standard treatment; CRQ, Chronic Respiratory Questionnaire; GARS; Groningen Activity and Restriction Scale; HADS, Hospital Anxiety and Depression Scale (separate scores for anxiety and depression domain); ITT, intention-to-treat; MRC, Medical Research Council dyspnoea scale; MRF-28, Maugeri Respiratory Failure Questionnaire-28; n, numbers for analysis; NIV, non-invasive positive pressure ventilation; SRI, Severe Respiratory Insufficiency questionnaire.