Table 4

Univariate associations with clinical deterioration or need for hospital-based intervention within 5 days of PE diagnosis

Variable	# with trait	% with trait	Primary outcome			Severe outcome			30-day mortality
Variable	# with trait	% with trait	% of patients without trait with outcome	% of patients with trait with outcome	p-Value	% of patients without trait with outcome	% of patients with trait with outcome	p-Value	% of patients without trait with outcome	% of patients with trait with outcome	p-Value
Age ≥65 years	117	39	28	44	0.004	8	11	0.321	2	7	0.045
Highest HR >100 bpm	105	35	30	41	0.058	7	12	0.141	4	5	0.641
Lowest SBP <90 mm Hg	20	7	31	75	<0.001	7	35	<0.001	4	10	0.161
Highest RR >20 BrPM	91	31	27	49	<0.001	6	15	0.012	3	7	0.130
Lowest SaO₂ <95%	105	35	24	52	<0.001	6	15	0.006	3	7	0.084
White race	268	90	27	35	0.378	10	9	0.850	0	4	0.236
Coronary artery disease	26	9	31	62	0.002	9	8	0.799	4	8	0.322
Congestive heart failure	12	4	33	50	0.229	9	8	0.929	4	17	0.023
Chronic lung disease	48	16	32	42	0.214	8	15	0.146	3	10	0.014
Malignancy	107	36	30	40	0.086	9	8	0.770	1	9	<0.001
Malignancy (active)	54	18	33	37	0.590	10	4	0.130	1	17	<0.001
Chronic renal insufficiency	8	3	33	50	0.329	9	13	0.731	4	14	0.164
Cerebrovascular disease	20	7	32	55	0.039	9	10	0.880	4	0	0.342
D-dimer ≥3000 mcg/mL	133	45	30	39	0.088	7	11	0.231	4	5	0.693
Troponin-T ≥0.1 ng/mL	12	4	33	50	0.229	8	25	0.050	4	8	0.441
NT-proBNP ≥200 pg/mL	128	43	25	46	<0.001	3	17	<0.001	2	6	0.087
PE central*	139	47	31	37	0.230	4	14	0.003	5	3	0.340
PE multiple	203	68	27	37	0.104	11	8	0.546	4	4	0.898
Residual DVT	74	25	29	47	0.005	8	14	0.124	4	5	0.472
Right heart strain on echocardiogram†	52	17	28	63	<0.001	4	31	<0.001	4	4	0.962

Significant associations are highlighted.
*Central PE is defined as any clot proximal to the segmental pulmonary arteries.
†Right heart strain on echocardiogram includes any finding of right ventricular hypertrophy, right ventricular dilatation or bowing of the intraventricular septum towards the left ventricle.
BrPM, breaths per minute; DVT, deep vein thrombosis; HR, heart rate; NT-proBNP, N-terminal brain natriuretic peptide; RR, respiratory rate; SBP, systolic blood pressure; SaO₂, oxygen saturation in capillary blood measured by pulse oximetry.