Table 2

Comparison of anthropometry and pulmonary function at ∼3 months and 1 year in CF NBS infants and healthy controls (HC)

 3 months1 yearChange over time (1 year–3 months)
CF (n=72)HC (n=44)CF−HC*CF (n=72)HC (n=44)CF−HC*CF: Change 1 year−3 months†HC: Change 1 year−3 months†Difference in change‡ CF−HC
Age at test, weeks§11.2 (2.3)12.1 (2.1)−1.0 (−1.8 to −0.1)52.4 (5.3)53.7 (4.4)−1.3 (−3.1 to 0.5)41.2 (37.3 to 43.1)41.6 (38.6 to 43.6)−0.36 (−2.30 to 1.58)
Weight z-score¶−0.89 (1.03)0.01 (0.97)−0.90 (−1.27 to −0.52)0.32 (0.90)0.55 (1.21)−0.23 (−0.64 to 0.19)1.21 (1.02 to 1.40)0.54 (0.28 to 0.80)0.67 (0.35 to 0.99)
Length z-score¶−0.21 (1.01)0.73 (0.92)−0.94 (−1.30 to −0.58)0.47 (1.01)0.76 (1.20)−0.28 (−0.71 to 0.15)0.68 (0.52 to 0.85)0.03 (−0.19 to 0.25)0.66 (0.38 to 0.93)
BMI z-score¶−1.08 (0.99)−0.55 (0.96)−0.53 (−0.90 to −0.16)0.08 (0.83)0.18 (1.12)−0.10 (−0.49 to 0.29)1.15 (0.95 to 1.37)0.72 (0.43 to 1.01)0.44 (0.07 to 0.80)
LCI z-score0.83 (1.32)0.36 (0.85)0.47 (0.06 to 0.87)1.05 (1.23)0.25 (0.95)0.80 (0.40 to 1.21)0.24 (−0.12 to 0.59)−0.09 (−0.46 to 0.28)0.33 (−0.18 to 0.84)
FRCpleth z-score0.75 (1.07)−0.01 (1.08)0.77 (0.32 to 1.22)0.75 (1.14)−0.05 (0.96)0.80 (0.40 to 1.20)−0.04 (−0.32 to 0.23)−0.04 (−0.45 to 0.36)0.00 (−0.48 to 0.49)
ΔFRC z-scores (pleth − MBW)0.59 (0.96)0.22 (0.94)0.37 (−0.32 to 0.77)1.21 (0.86)0.46 (0.69)0.75 (0.44 to 1.06)0.58 (0.26 to 0.89)0.30 (−0.09 to 0.68)0.28 (−0.21 to 0.77)
FVC z-score−0.50 (1.03)0.23 (0.67)−0.74 (−1.06 to −0.41)−0.43 (1.16)0.23 (0.94)−0.66 (−1.05 to −0.26)0.06 (−0.18 to 0.29)−0.02 (−0.31 to 0.28)0.08 (−0.29 to 0.45)
FEV0.5 z-score−1.23 (1.07)−0.16 (0.76)−1.07 (−1.42 to −0.73)−0.41 (1.03)0.12 (0.92)−0.52 (−0.89 to −0.15)0.83 (0.56 to 1.09)0.24 (−0.07 to 0.56)0.59 (0.18 to 0.99)
FEF75 z-score−0.76 (1.25)−0.07 (0.96)−0.69 (−1.11 to −0.27)−0.09 (0.93)0.09 (0.91)−0.18 (−0.54 to 0.18)0.84 (0.48 to 1.19)0.20 (−0.17 to 0.58)0.63 (0.12 to 1.14)
  • Data shown as mean (SD) or mean difference (95% CI) between: *Groups, †Test occasions.

  • ‡Change over time between groups (CF- HC); significant differences (p <at least 0.05) are shown in bold.

  • §Corrected for gestational age.

  • ¶Calculated according to Cole et al.13

  • BMI, Body Mass Index; CF, cystic fibrosis; FRCpleth, plethysmographic functional residual capacity; ΔFRC z-scores (pleth − MBW), difference between FRCpleth and FRCMBW z-scores as a measure of gas trapping; FVC, forced vital capacity; FEV0.5, forced expired volume in 0.5 s; FEF75, forced expired flow when 75% of FVC has been expired; LCI, Lung Clearance Index; MBW, multiple breath inert gas washout; NBS, newborn screened.