Comparison of costs and QALYs from devices against control
| Intervention | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cost component (£) | No treatment n=78 | SP1 n=81 | SP2 n=78 | bMAD n=77 | ||||
| Device (fixed) | – | £21 | £128 | £350 | ||||
| Measurement for device (fixed) | – | – | – | £110.37 | ||||
| Fitting of device (fixed) | – | – | – | £92.04 | ||||
| Additional visit if required (average across all patients) | – | – | – | £5.98 | ||||
| Subtotal | – | £21 | £128 | £350 | ||||
| Device lifespan (months) (fixed) | – | 12 | 12 | 18 | ||||
| Cost of intervention subtotal pro rata (4 weeks) (fixed)* | – | £1.62 | £9.85 | £28.64 | ||||
| Summary of costs (£) | Mean | SE | Mean | SE | Mean | SE | Mean | SE |
| Resource use cost (4 weeks) Mean (SD)† | £78.50 | £19.97 | £73.02 | £10.47 | £53.58 | £8.05 | £76.25 | £24.40 |
| Total cost (4 weeks) Mean (SD)† | £78.50 | £19.97 | £74.64 | £10.47 | £63.43 | £8.05 | £104.89 | £24.39 |
| Total cost difference intervention vs control | – | – | −£3.87 | £21.38 | −£15.08 | £20.62 | £26.39 | £27.94 |
| Health-related quality of life measure | ||||||||
| EQ-5D-3L Utility score | 0.85 | 0.2 | 0.86 | 0.2 | 0.86 | 0.23 | 0.87 | 0.19 |
| EQ-5D-3L QALY score (4-week trial period)‡ | 0.0649 | 0.0017 | 0.0658 | 0.0017 | 0.0658 | 0.0019 | 0.0667 | 0.0017 |
| QALY score difference intervention vs control | – | – | 0.00094 | 0.00105 | 0.00088 | 0.00123 | 0.00177 | 0.00147 |
| Cost effectiveness measure | ||||||||
| Incremental Cost-Effectiveness Ratio | – | −£4093 | −£17 104 | £14 876 | ||||
| Net monetary benefit (willingness-to-pay=£20 000) | – | £23 | £33 | £9 | ||||
*Device and fitting costs are pro rata to be comparable over the 4-week trial period.
†Resource use and total costs by intervention estimated using a mixed effects model controlling for baseline data. All costs in 2011/2012 (£).
‡QALY scores calculated using area under the curve method to represent the true QALY score for the 4-week intervention period and to be consistent with the costs presented.
bMAD, bespoke mandibular advancement device; QALY, quality-adjusted life year.