Table 4

Affinity of p26, 18 and 23 binding to HLA-DR and HLA-DQ molecules

DR1DR3DR4DR7DR9DR11DR13DR1501DR1502DQ6DQ8
14%30%20%25%1%14%16%27%2%16%21%
p26183510.314389116267
p1811nd0.332nd3>456422000ndnd
p231nd0.48nd2>456374ndnd
  • Results are expressed as a relative binding ratio obtained by dividing the IC50 of allergen peptide by that of a reference peptide that binds strongly to the HLA molecule. Lower numbers correspond to a higher binding affinity. Numbers in bold (ratio of 20 or less) = high affinity binding; numbers in italic (ratio 20–100) = moderate binding affinity. Each peptide—major histocompatibility complex combination was evaluated in two independent experiments. Percentages are the frequency of the HLA-DR or HLA-DQ alleles in a Caucasian population calculated from allele frequency net (http://www.allelefrequencies.net): a database and online repository for immune gene frequencies in worldwide populations.

  • HLA, human leukocyte antigen; nd, not done.