Occupational asbestos exposure and risk of pleural mesothelioma, 437 cases (362 men; 75 women) and 874 controls (724 men; 150 women), French case-control study, 1998–2002
| Men (1 086) | Women (225) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (362) | Controls (724) | Cases (75) | Controls (150) | |||||||||||
| Occupational asbestos exposure | n | % | n | % | OR | 99% CI | n | % | n | % | OR | 99% CI | ||
| Not exposed | 28 | 7.7 | 327 | 45.2 | 1.0 | – | 41 | 54.7 | 139 | 92.7 | 1.0 | – | ||
| Exposed | 334 | 92.3 | 397 | 54.8 | 11.4 | 6.1 to 21.4 | 34 | 45.3 | 11 | 7.3 | 12.0 | 3.5 to 41.7 | ||
| Highest probability of exposure | Possible | 43 | 11.9 | 102 | 14.1 | 5.6 | 2.6 to 12.1 | Possible | 19 | 25.3 | 8 | 5.3 | 9.6 | 2.4 to 38.1 |
| Definite | 291 | 80.4 | 295 | 40.7 | 13.2 | 7.0 to 25.0 | Definite | 15 | 20.0 | 3 | 2.0 | 18.2 | 2.9 to 112.9 | |
| Duration of exposure (years) | 1–10 | 71 | 19.6 | 119 | 16.4 | 7.9 | 3.8 to 16.1 | 1–10 | 19 | 25.3 | 4 | 2.7 | 36.2 | 2.6 to 513.3 |
| >10–20 | 78 | 21.6 | 95 | 13.1 | 11.2 | 5.4 to 23.3 | >10 | 15 | 20.0 | 7 | 4.6 | 6.6 | 1.6 to 27.8 | |
| >20 | 185 | 51.1 | 183 | 25.3 | 13.9 | 7.2 to 27.0 | ||||||||
| Age at first exposure (years) | ≤15 | 77 | 21.3 | 63 | 8.7 | 15.8 | 7.4 to 33.8 | ≤20 | 14 | 18.7 | 2 | 1.3 | 38.2 | 2.4 to 601.3 |
| >15–20 | 122 | 33.7 | 115 | 15.9 | 14.6 | 7.3 to 29.4 | >20 | 20 | 26.6 | 9 | 6.0 | 8.3 | 2.2 to 31.5 | |
| >20 | 135 | 37.3 | 219 | 30.2 | 8.5 | 4.4 to 16.4 | ||||||||
| Time since first exposure (years) | >19–40 | 81 | 22.4 | 119 | 16.4 | 8.3 | 4.0 to 17.2 | >19–40 | 15 | 20.0 | 5 | 3.3 | 10.2 | 2.0 to 50.5 |
| >40–50 | 114 | 31.5 | 131 | 18.1 | 12.6 | 6.2 to 25.6 | >40 | 19 | 25.3 | 6 | 4.0 | 14.2 | 2.7 to 75.0 | |
| >50 | 139 | 38.4 | 147 | 20.3 | 13.4 | 6.7 to 26.8 | ||||||||
| Year at first exposure | ≤1960 | 256 | 70.7 | 275 | 38.0 | 13.8 | 7.2 to 26.7 | ≤1960 | 19 | 25.3 | 6 | 4.0 | 14.3 | 2.7 to 75.8 |
| >1960–1977 | 75 | 20.7 | 108 | 14.9 | 8.4 | 4.0 to 17.6 | >1960–1977 | 13 | 17.3 | 4 | 2.7 | 10.6 | 2.1 to 55.9 | |
| >1977 | 3 | 0.9 | 14 | 1.9 | 1.9 | 0.3 to 11.8 | >1977 | 2 | 2.7 | 1 | 0.6 | 7.9 | 0.2 to 258.8 | |
| Cumulative exposure (« f/mL-years ») | >0–0.1 | 54 | 14.9 | 181 | 25.0 | 4.0 | 1.9 to 8.3 | >0 to 0.1 | 13 | 17.3 | 6 | 4.0 | 6.9 | 1.5 to 30.9 |
| >0.1–1 | 68 | 18.8 | 121 | 16.7 | 8.3 | 3.8 to 17.7 | >0.1 | 21 | 28.0 | 5 | 3.3 | 23.7 | 3.3 to 168.53 | |
| >1–10 | 115 | 31.8 | 68 | 9.4 | 22.5 | 10.4 to 48.7 | ||||||||
| >10 | 97 | 26.8 | 27 | 3.7 | 67.0 | 25.6 to 175.1 | ||||||||
| Attributable risk (99% CI) (%) | 83.1 (74.5 to 91.7) | 41.7 (25.3 to 58.0) | ||||||||||||