Single nucleotide polymorphisms (SNPs) associated with smoking cessation with meta-analytic p<10−5, and a candidate SNP (last row) from the dopamine beta-hydroxylase (DBH) locus identified by previous genome-wide association studies (GWAS) on smoking cessation
| Chr. | Top SNP | Nearest gene within 50 kb | Effect/non-effect allele | OR | p | I2 | Q stat. | N/Nimp | Freq. | Effect direction consistent with previous GWAS |
| 10 | rs10794613 | FLJ46361 (5′ region) | G/C | 1.43 | 3.41×10−6 | 0 | 0.51 | 3/3 | 0.21 | – |
| 3 | rs13064954 | CCNL1 (3′ region) | A/G | 1.94 | 5.28×10−6 | 0 | 0.60 | 3/2 | 0.05 | – |
| 10 | rs1896376 | CPMX2 (intron) | C/T | 1.83 | 5.71×10−6 | 57 | 0.10 | 3/2 | 0.95 | – |
| 13 | rs9506942 | – | C/G | 1.29 | 5.96×10−6 | 0 | 0.72 | 3/3 | 0.57 | – |
| 13 | rs9552733 | – | G/A | 1.29 | 5.99×10−6 | 0 | 0.69 | 3/0 | 0.57 | – |
| 3 | rs9866141 | VEPH1 (3′ region) | T/C | 1.88 | 7.99×10−6 | 0 | 0.66 | 3/3 | 0.06 | – |
| 3 | rs1165640 | – | C/T | 1.56 | 8.98×10−6 | 0 | 0.57 | 3/0 | 0.10 | – |
| 12 | rs10861185 | TXNRD1 (intron) | C/A | 1.29 | 9.57×10−6 | 16 | 0.31 | 3/2 | 0.57 | – |
| 10 | rs727417 | CPXM2 (intron) | C/G | 1.71 | 9.67×10−6 | 38 | 0.20 | 3/3 | 0.94 | – |
| 9 | rs3025343 | DBH (5′ region) | G/A | 1.24 | 0.015 | 46 | 0.16 | 3/3 | 0.87 | Yes |
Analyses were adjusted for age, % of predicted forced expiratory volume in 1 s (FEV1) and principal components for genetic ancestry. Patients who were current smokers were considered as ‘controls’, while patients who were former smokers were considered as ‘cases’.
P values < 0.05 are depicted in bold. N/Nimp, number of studies contributing to the meta-analysis/number of studies in which SNP was imputed; I2, heterogeneity index; Q stat., p value for Q statistic; p, p value from the fixed effect meta-analysis; Freq., effect allele frequency in 3441 patients with at least one non-missing phenotype from four cohorts studied; Chr., chromosome.