Table 5

Risk of a prothrombotic state* in people with IPF stratified by pulmonary function indices

Pulmonary function indicesNumber of cases (%) (n=211)OR (95% CI)†OR (95% CI)‡
% predicted FVC
 ≥10136 (17.1)1.001.00
 86–10053 (25.1)1.84 (0.71 to 4.76)2.10 (0.76 to 5.81)
 71–8568 (32.2)3.48 (1.30 to 9.30)4.04 (1.43 to 11.37)
 ≤7043 (20.4)9.04 (2.24 to 36.43)
p for trend=0.536
10.79 (2.43 to 47.91)
p for trend=0.610
Missing values10 (5.2)
% predicted Tlco
 ≥6026 (12.3)1.001.00
 46–5959 (28.0)2.17 (0.77 to 6.17)3.37 (1.09 to 10.43)
 31–4582 (38.9)3.77 (1.32 to 10.79)6.25 (1.95 to 19.99)
 ≤3024 (11.4)1.80 (0.51 to 6.37)
p for trend=0.124
2.81 (0.72 to 10.94)
p for trend=0.152
Missing values20 (9.5)
  • *A prothrombotic state is a composite binary variable where at least a single clotting defect was present on laboratory testing.

  • †ORs adjusted for age category and sex.

  • ‡ORs adjusted for age category, sex, smoking and hsCRP category.

  • FVC, forced vital capacity; hsCRP, highly sensitive C reactive protein; IPF, idiopathic pulmonary fibrosis; Tlco, carbon monoxide transfer factor.