Table 4

Systemic and pulmonary haemodynamics and oxygenation at baseline compared with 12 weeks after parenteral treprostinil therapy

Baseline
N=15
Mean (SD)
12 weeks
N=15
Mean (SD)
p Value*
 Haemodynamics, mm Hg
 Right atrial pressure9.5 (3.4)6.0 (3.7)<0.001
 Mean pulmonary pressure47.0 (8.0)38.9 (13.4)0.005
 Pulmonary artery wedge pressure12.5 (4.1)10.5 (6.1)0.247
 Cardiac output (L/min)4.3 (1.1)4.9 (1.1)0.042
 Cardiac index (L/min/m2)2.3 (0.5)2.7 (0.6)0.017
 PVR (dyn s/cm5)698 (278)496 (229)<0.001
 Mixed venous O2 saturation (%)65 (7.2)70.9 (7.4)0.023
 Haemoglobin (g/dL)14.1 (2.1)13.6 (2.2)0.310
 Arterial O2 content (mL O2/100 mL)16.6 (3.1)15.4 (3.6)0.086
 O2 delivery (mL/min)†6332 (2295)7263 (5337)0.246†
 Pulmonary capacitance (mL/mm Hg)‡1.28 (0.54)1.64 (0.91)0.013
 RV pulsatility0.94 (0.16)1.04 (0.16)0.010
 Pulse pressure44.1 (8.9)40.3 (14.1)0.182
 Stroke volume (mL) †51.8 (8.7)61.8 (21.7)0.031†
 Stroke volume index29.2 (6.7)33 (7.3)0.037
 Systolic blood pressure†125 (25)109 (13)0.028†
 Mean arterial pressure88.6 (15.8)84.8 (9.4)0.278
 HR (beats/min)79 (9.9)80 (11.8)0.490
 Rs (dyn s/cm5)1575 (487)1306 (357)0.015
 PVR/SVR0.46 (0.13)0.39 (0.15)0.060
 TPG34.7 (8.7)28.5 (10.3)0.014
 BNP (pg/mL)558 (859)228 (340)0.004†
  • *Paired t test p value presented, except when Wilcoxon signed rank indicated.

  • †Data are non-normally distributed; median (IQR) and Wilcoxon signed rank p value presented.

  • ‡Pulmonary capacitance = stroke volume/pulse pressure.

  • BNP, brain natriuretic peptide; PVR, pulmonary vascular resistance; RV, right ventricular; SVR, systemic vascular resistance; TPG, transpulmonary gradient.