Table 1

Clinical features of infants with NBS-diagnosed CF undergoing CT at 1 year of age

N (% boys)65 (48)
Age at diagnosis, weeks*3.4 (3.0−4.4)
Pancreatic insufficiency, n (%)61 (94)
Meconium ileus, n (%)7 (11)
Delta F508†, n (%)58 (89)
Age at time of test, weeks52.7 (4.7)
Somatic growth
Weight, z score‡0.34 (0.10)
Length, z score‡0.49 (0.97)
Body mass index, z score‡0.09 (0.84)
Before 1 year CT assessments
Respiratory symptoms, ever:
 Wheeze, physician-diagnosed22 (34)
 Crackles, physician-diagnosed7 (11)
Bacterial growth on cough swab, ever§
Pseudomonas aeruginosa20 (31)
 Other significant bacterial growth**24 (37)
 No growth††21 (32)
  • Results expressed as mean (SD) or n (%) unless otherwise stated.

  • *Median (IQR).

  • †Homozygous or heterozygous.

  • ‡Calculated according to Cole et al.26

  • §Based on the presence of bacteria ever isolated in the first year.

  • ¶Definition of colonisation according to Lee et al27; only 2/65 (3%) infants had any evidence of Pseudomonas aeruginosa (PsA) on bronchoalveolar lavage or cough swab within 5 days of the CT scan.

  • **Significant bacterial growth consisted of those who had methicillin-sensitive or methicillin-resistant Staphylococcus aureus (MSSA or MRSA, respectively), Haemophilus influenza (HI), Stenotrophomonas maltophilia, Acromobacter xylosidans or Aspergillus fumigatus with no previous growth of PsA.

  • ††No bacterial growth consisted of those with isolation of coliforms and upper respiratory tract flora only.

  • CF, cystic fibrosis; NBS, newborn screened.