Clinical and biological data at presentation of patients with acute chest syndrome and a new pulmonary opacity on CT
| At least one complete lung segment consolidation on CT | |||
|---|---|---|---|
| Parameter | No (n=55) | Yes (n=84) | p Value |
| Presence of a precipitating factor | 24 (44%) | 57 (68%) | <0.01 |
| Type of precipitating factor | 0.02 | ||
| Extrathoracic pain before ACS | 7 (13%) | 30 (15%) | |
| Surgery | 2 (4%) | 5 (6%) | |
| Infection | 2 (4%) | 6 (7%) | |
| Other | 13 (24%) | 16 (19%) | |
| Symptoms | |||
| Fever | 18 (34%) | 37 (45%) | 0.22 |
| Chest pain | 51 (96%) | 81 (96%) | >0.99 |
| Extrathoracic pain during ACS | 47 (89%) | 60 (71%) | 0.02 |
| Haemoptysis | 0 (0%) | 2 (2%) | 0.52 |
| Cough | 22 (42%) | 34 (41%) | 0.91 |
| Pulmonary crackles | 39 (74%) | 71 (85%) | 0.12 |
| Jugular venous distension | 2 (4%) | 7 (8%) | 0.48 |
| Blood pressure, mmHg | |||
| Systolic | 120 [110–130] | 120 [114–130] | 0.07 |
| Diastolic | 66 [65–74] | 70 [65–76] | 0.20 |
| Heart rate, beats/minute | 100 [99–120] | 110 [100–120] | 0.12 |
| Respiratory rate, breaths/minute | 26 [24–28] | 28 [26–30] | <0.01 |
| Blood gases | |||
| PaO2, mmHg | 74 [64–93] | 77 [65–96] | 0.49 |
| PaO2/FiO2 ratio, mmHg | 305±75 | 285±101 | 0.22 |
| PaCO2, mmHg | 43±7 | 44±6 | 0.21 |
| pH | 7.41±0.05 | 7.40±0.05 | 0.29 |
| HCO3−, mmol/L | 28±3 | 28±3 | 0.98 |
| SaO2, % | 95 [90–97] | 94 [91–98] | 0.70 |
| Laboratory values at ACS diagnosis | |||
| White cell count, 109/L | 14.6±5.3 | 18.0±6.0 | <0.01 |
| Platelet count, 109/L | 353±143 | 374±218 | 0.54 |
| Total haemoglobin, g/dL | |||
| All patients | 9.1±1.5 | 8.7±1.6 | 0.26 |
| SS patients only (n=123 episodes) | 9.0±1.5 | 8.5±1.5 | 0.07 |
| Creatinine, µmol/L | 65±21 | 60±28 | 0.24 |
| C-reactive protein, mg/L | 98±94 | 141±94 | 0.02 |
| Alkaline phosphatase, IU/L | 91 [73–126] | 101 [76–136] | 0.41 |
| Aspartate aminotransferase, IU/L | 48 [31–66] | 40 [29–68] | 0.40 |
| Alanine aminotransferase, IU/L | 28 [20–59] | 29 [18–48] | 0.89 |
| Total bilirubin, µmol/L | 45 [29–71] | 39 [26–64] | 0.57 |
| Direct bilirubin, µmol/L | 11 [7–15] | 12 [8–19] | 0.27 |
| Lactate dehydrogenase, IU/L | 552 [389–734] | 491 [360–652] | 0.17 |
| CT | |||
| Pulmonary artery thrombosis | 9 (16%) | 17 (20%) | 0.57 |
| Right ventricle/left ventricle ratio | 0.92 [0.81–1.05] | 0.91 [0.81–1.09] | 0.89 |
| Moderate to large pleural effusion | 6 (11%) | 27 (32%) | <0.01 |
Data are presented as mean±SD, median [25th–75th percentiles] or number (percentage).
ACS, acute chest syndrome.