Table 3

Mantel summary statistics for all communities, and the core and satellite species groups.

Mantel testAllCoreSatellite
Parameter AParameter Brp Valuerp Valuerp Value
SimilarityFEV1% (pre BD)−0.167<0.0001*−0.167<0.0001*−0.0870.007
SimilarityFEV1% (post BD)−0.182<0.0001*−0.182<0.0001*−0.0890.006
  • The Mantel statistic r(AB) estimates the correlation (Pearson's correlation coefficient) between two proximity matrices, A and B, and p is used to ascertain whether Mantel regression coefficients were significantly different from 0 following 9999 Monte Carlo permutations. Mantel tests are presented between bacterial community similarity (Bray–Curtis index) and differences in clinical factors.

  • *p values significant after Bonferroni correction for multiple comparisons (0.05/10=0.005).

  • BD, bronchodilator; FEV1, forced expiratory volume in 1 s; LCS, Leicester Cough Score.