Association of DM with selected clinical manifestations and treatment outcomes among patients with pulmonary TB by multivariate analyses
| Variable | Cavities on chest x-ray OR† (95% CI) n=1051 | Sputum conversion ≥60 days OR† (95% CI) n=639 | Treatment failure OR† (95% CI) n=756‡ | Recurrence HR§ (95% CI) n=842 | Relapse HR§ (95% CI) n=731 |
|---|---|---|---|---|---|
| Diabetes | 1.80 (1.35 to 2.41)* | 1.51 (1.09 to 2.10)*** | 2.93 (1.18 to 7.23)*** | 1.76 (1.11 to 2.79)*** | 1.83 (1.04 to 3.23)*** |
| Men | – | 2.9 (1.02 to 8.24)*** | – | – | |
| >10 cigarettes per week | – | – | – | – | 2.86 (1.42 to 5.75)** |
| Previous TB treatment | – | – | 5.1 (2.00 to 13.00)** | – | – |
| Time elapsed between onset of symptoms and treatment | – | 1.01 (1.01 to 1.01)*** | – | – | – |
| >10 bacilli per oil immersion field | 2.11 (1.57 to 2.84)** | – | – | – | 2.00 (1.09 to 3.64)*** |
| Joint resistance to isoniazid and rifampin | – | 5.80 (1.63 to 29.71)** | 37.46 (12.21 to 114.85)* | 8.41(4.57 to 15.46)* | 12.85 (4.91 to 33.58)* |
| Failure or default | – | – | – | 4.83 (2.79 to 8.35)* | – |
| HIV infection | 0.32 (0.09 to 1.12)¶ | – | – | 4.23 (1.03 to 17.42)*** | – |
| Body mass index | 0.95 (0.92 to 0.98)** | – | – | – | – |
*p<0.001; **p<0.01; ***p<0.05.
†Unconditional logistic regression model.
‡Patients who failed were compared with patients who cured or completed treatment - variable not included in the final model.
§Cox proportional hazards model.
¶Not significant
DM, diabetes mellitus; TB, tuberculosis.