Table 5

Crude and adjusted rate ratios of serious pneumonia associated with current use of fluticasone and budesonide, stratified by prior COPD hospitalisation

ICS exposureCasesControlsCrude rate ratioAdjusted* rate ratio95% CI
Prior COPD hospitalisation
 Number of subjects29758249
 No use, %†23.0330.561.001.00Reference
 Fluticasone current use, %‡39.3627.481.961.751.56 to 1.97
 Budesonide current use, %‡5.715.321.391.190.97 to 1.47
No prior COPD hospitalisation
 Number of subjects17 369189 456
 No use, %†50.4862.481.001.00Reference
 Fluticasone current use, %‡21.9911.582.472.011.92 to 2.10
 Budesonide current use, %‡5.074.801.341.141.06 to 1.23
  • *Adjusted for all of the factors listed in table 1.

  • †No use in the year prior to the index date.

  • ‡Current use refers to a prescription in the 60 days prior to the index date.

  • COPD, chronic obstructive pulmonary disease; ICS, inhaled corticosteroid.