Different clinical phenotypes of active tuberculosis stratified by lineage and demographic group
| Clinical phenotype and demographic group | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary only (n=545)* | Extrathoracic only (n=317)* | ||||||||
| Mycobacterial lineage | UK born white | UK born non-white | Foreign born non-white | Total†¶ | UK born white | UK born non-white | Foreign born non-white | Total‡¶ | p Value§¶ |
| East Asian | 12 (100.0) | 5 (62.5) | 34 (43.0) | 51 | 0 (0.0) | 3 (37.5) | 45 (57.0) | 48 | <0.0001 |
| Euro-American | 88 (97.8) | 62 (77.5) | 118 (58.7) | 268 | 2 (2.2) | 18 (22.5) | 83 (41.3) | 103 | <0.0001 |
| East African Indian | 19 (95.0) | 33 (73.3) | 118 (58.1) | 170 | 1 (5.0) | 12 (26.7) | 85 (41.9) | 98 | 1.00 |
| Indo-Oceanic | 1 (100.0) | 8 (61.5) | 47 (41.9) | 56 | 0 (0.0) | 5 (38.5) | 63 (57.3) | 68 | <0.0001 |
*The figures presented in each column refer to the number of cases and percentage. Percentages of cases that were pulmonary only and extrathoracic only are calculated for each lineage and demographic group separately. Data for extrapulmonary TB and lymph node TB not shown but results are essentially the same as those shown in table 4 for extrathoracic TB disease.
†Total refers to the total number of cases that were pulmonary only for each lineage (ie should be read across).
‡Total refers to the total number of case that were extrathoracic only for each lineage (ie should be read across).
§p Value refers to the comparison between the three demographic groups (UK-born white versus UK-born non-white versus foreign-born non-white) of the proportion of cases that are extrathoracic only for each lineage in turn; data analysed using Fisher's exact test.
¶For the total cohort the East Asian (51/545, 9.4% vs 48/317, 15.1%; p=0.014) and Indo-Oceanic lineages (51/545, 9.4% vs 48/317, 15.1%; p=0.014) were significantly more likely to cause extrathoracic only disease compared with pulmonary only disease whereas the Euro-American lineage was significantly more likely to cause pulmonary only disease than extrathoracic only disease (268/545, 49.2% vs 103/317, 32.5%; p<0.0001); data analysed using Fisher's exact test.
TB, tuberculosis.