Table 2

Rates of exacerbations and structural and functional outcomes at age 5 years

BronchiectasisAir trappingFEV1 z score*Weight z score†
ExacerbationsOR‡95% CIp ValueOR‡95% CIp ValueCoeff‡95% CIp ValueCoeff‡95% CIp Value
Total exacerbations1.450.98 to 2.140.061.240.84 to 1.830.27−0.25−0.51 to 0.000.050.06−0.09 to 0.220.42
PsA adjusted1.410.95 to 2.090.091.200.81 to 1.770.37−0.24−0.50 to 0.030.080.08−0.08 to 0230.32
Exacerbations in the first 2 years1.150.90 to 1.470.251.270.99 to 1.640.06−0.20−0.36 to −0.050.012−0.08−0.18 to 0.020.10
PsA adjusted1.140.89 to 1.450.311.250.97 to 1.610.09−0.20−0.35 to −0.040.017−0.08−0.18 to 0.020.13
Hospital exacerbation ever2.671.13 to 6.310.032.420.99 to 5.900.05−0.52−1.04 to 0.000.05−0.39−0.74 to −0.050.03
PsA adjusted2.340.93 to 5.920.072.020.77 to 5.270.15−0.50−1.08 to 0.080.09−0.33−0.71 to 0.040.08
  • *FEV1 z score determined from normal values (http://www.lungfunction.org/growinglungs).

  • †Weight z score determined from normal values (http://www.cdc.gov/growthcharts).

  • ‡The OR and regression coefficients for total exacerbations and exacerbations over the first 2 years refer to a log2 unit (a doubling) of exacerbation rate.

  • FEV1, forced expiratory volume in 1 s; PsA, Pseudomonas aeruginosa.