Severe asthma | Mild to moderate asthma | p Value | |
---|---|---|---|
Patients in the BIOAIR cohort (n) | 93 | 76 | ND |
Age (years) (min–max) | 50.0±1.3 (18–72) | 42.2±1.5 (20–70) | 0.001* |
Women (%) | 58 | 61 | 0.982† |
FEV1 (% pred) | 70.4±2.1 | 88.7±2.1 | <0.0001* |
FEV1 (litres) | 2.04±0.08 | 2.79±0.08 | <0.0001* |
FEV1/FVC | 0.67±0.01 | 0.70±0.01 | 0.093* |
Reversibility (% of change) | 9.4±0.8 | 10.6±0.7 | 0.192* |
ICS (median (mean±SD)) Beclomethasone eq. | 1600 µg* (2064±939.7) | 800 µg (614±218.6) | <0.0001* |
OCS (median (mean±SD; min–max)) prednisolone eq. | 10 mg (14.15±11.8; 2–50) | – | ND |
BMI (kg/m2) | 28.5±0.6 | 25.0±0.4 | <0.0001* |
ACQ (Juniper) | 2.03±0.1 | 1.03±0.7 | <0.0001* |
QoL (SGRQ) | 45.9±2.1 | 22.5±2.0 | <0.0001* |
CRP (mg/litre) | 6.1±0.9 | 3.5±0.6 | 0.092* |
Atopy (%) | 43 | 48 | 0.642† |
FENO (ppb) | 46.3±6.2 | 40.1±4.1 | 0.962* |
Sputum cells (×106) | 3.34±1.02* | 1.83±0.34 | 0.455* |
Sputum eosinophils (%) | 16.7±3.49* | 5.79±1.71 | 0.018* |
Sputum neutrophils (%) | 42.2±3.7 | 44.2±4.4 | 0.338* |
Atopy defined as at least one positive skin prick test. p<0.05
*Mann–Whitney U test.
†χ2 test.12
ACQ, Asthma Control Questionnaire; BIOAIR, Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease; BMI, body mass index; CRP, serum C-reactive protein; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; ICS, inhaled corticosteroids; ND, not determined; OCS, oral corticosteroid; QoL, quality of life; SGRQ, St George's Respiratory Questionnaire.