Treatment outcomes among patients with pulmonary TB with and without DM (Orizaba, Veracruz, Mexico, 1995–2010)
| Outcome | Total number of TB patients n/total (%) | TB patients with DM n/total (%) | TB patients without DM n/total (%) | p Value* |
|---|---|---|---|---|
| Outcomes during and at the end of treatment | ||||
| Sputum conversion after ≥60 days | 350/873 (40.10) | 133/290 (45.86) | 217/583 (37.22) | 0.014 |
| Failure | 36/1210 (2.97) | 17/363 (4.68) | 19/847 (2.24) | 0.022 |
| Cure | 864/1210 (71.40) | 259/363 (71.35) | 605/847 (71.43) | 0.978 |
| Treatment completion | 155/1210 (12.81) | 49/363 (13.50) | 106/847 (12.51) | 0.639 |
| Death during treatment | 47/1210 (3.88) | 11/363 (3.03) | 36/847 (4.25) | 0.314 |
| Default | 95/1210 (7.85) | 23/363 (6.34) | 72/847 (8.50) | 0.200 |
| Transfer out | 13/1210 (1.07) | 4/363 (1.10) | 9/847 (1.06) | 0.951 |
| Outcomes after treatment was completed | ||||
| Recurrence† ‡ | 107/1163 (9.20) | 41/352 (11.65) | 66/811 (8.14) | 0.057 |
| Identical strains in first and second episodes | 55/64 (85.94) | 21/26 (80.77) | 34/38 (89.47) | 0.325 |
| Different strains in first and second episodes | 9/64 (14.06) | 5/26 (19.23) | 4/38 (10.53) | |
| Relapse§,† | 74/1019 (7.26) | 26/308 (8.44) | 48/711 (6.75) | 0.340 |
| Identical strains in first and second episodes | 31/38 (81.58) | 10/13 (76.92) | 21/25 (84.00) | 0.593 |
| Different strains in first and second episodes | 7/38 (18.42) | 3/13 (23.08) | 4/25 (16.00) | |
| Deaths after TB treatment was completed¶ | ||||
| Death due to TB | 50/1198 (4.17) | 9/359 (2.51) | 41/839 (4.89) | 0.059 |
| Death by some cause other than TB | 203/1198 (16.94) | 104/359 (28.97) | 99/839 (11.80) | <0.001 |
*χ2 test.
†We were able to fingerprint both isolates for 59.81% (64/107) of the patients with a recurrence, including 51.35% (38/74) of the patients with a relapse.
‡Comparison of fingerprints of first or subsequent isolates among 19 patients who recurred after default revealed matching fingerprints in 14 patients. In five patients we were unable to obtain DNA on isolates of both episodes. Of the 13 patients who recurred after failure, 9 had matching fingerprints, 2 had different fingerprints and in 2 patients we were unable to obtain DNA on isolates of both episodes.
§Relapse patients are included within recurrent TB.
¶Six of 17 patients who died who did not accept treatment were excluded.
DM, diabetes mellitus; TB, tuberculosis.