Table 3

Associations between 5-year outcomes and reporting of specific symptoms/signs during exacerbations

OutcomeSymptomSymptom ever reportedSymptom never reportedOR95% CIp Value
Parent-reported symptoms
Bronchiectasis on CT scan (n=153)Wheeze57% (62/108)56% (25/45)1.080.53 to 2.170.83
Fever56% (75/133)60% (12/20)0.860.33 to 2.250.76
Air trapping on CT scan (n=154)Wheeze54% (59/110)25% (11/44)3.471.59 to 7.560.002
Fever43% (58/134)60% (12/20)0.510.20 to 1.330.17
FEV1 z score* (n=128)nMeanSDnMeanSDDiff in means95% CIp Value
Wheeze98−0.551.1930 −0.131.08−0.43−0.91 to 0.060.08
Fever112−0.481.1816−0.261.19−0.22−0.84 to 0.410.49
Weight z score† (n=157)
Wheeze111−0.240.8546−0.030.84−0.21−0.50 to 0.090.16
Fever135−0.140.8522−0.450.800.31−0.07 to 0.700.11
Doctor-reported symptoms
Bronchiectasis on CT scan (n=153)Wheeze67% (43/64)49% (44/89)2.091.07 to 4.080.03
Crackles62% (34/55)54% (53/98)1.370.70 to 2.700.36
Chest retractions59% (36/61)55% (51/92)1.160.60 to 2.230.66
Air trapping on CT scan (n=154)Wheeze51% (33/65)42% (37/89)1.450.76 to 2.760.26
Crackles55% (30/55)40% (40/99)1.770.91 to 3.440.09
Chest retractions53% (32/60)40% (38/94)1.680.88 to 3.240.12
FEV1 z score* (n=128)nMeanSDnMeanSDDiff in means95% CIp Value
Wheeze54−0.601.2674−0.341.11−0.25−0.67 to 0.160.23
Crackles44−0.681.3284−0.331.09−0.34−0.77 to 0.090.12
Chest retractions51−0.801.3077−0.221.03−0.59−1.00 to −0.180.005
Weight z score† (n=157)
Wheeze66−0.340.8691−0.070.82−0.27−0.54 to 0.000.05
Crackles55−0.200.80102−0.170.88−0.03−0.31 to 0.250.85
Chest retractions62−0.370.8895−0.060.81−0.31−0.58 to −0.040.02