Table 5

Treatment comparisons versus placebo for change from baseline in mean rescue medication usage at week 6

Rescue medication usage (daily no. of puffs averaged over each week)PlaceboPH-797804 dose
0.5 mg3 mg6 mg10 mg
N (baseline)4016436342
Baseline, mean (SD)3.40 (2.84)2.03 (2.30)3.50 (2.47)3.42 (4.81)2.55 (2.34)
N (week 6)3815405438
Adjusted mean change (puffs per day)0.3090.025−0.165−0.3510.115
SE of the mean0.2490.3950.2410.2040.246
95% CI(−0.183 to 0.801)(−0.754 to 0.805)(−0.641 to 0.311)(−0.753 to 0.052)(−0.372 to 0.601)
Difference between means*−0.283−0.473−0.659−0.194
SE of difference*0.4670.3460.3220.351
95% one-sided lower limit for difference*0.4900.100−0.1270.386
p Value (difference between means)*0.2730.0870.0210.291
  • *Comparisons are between each dose of PH-797804 and placebo using the full analysis set, which included all patients who were randomised and had a valid FEV1 measurement during the double-blind treatment phase.

  • FEV1, forced expiratory volume in 1 s;