Spirometric variables at Week 6
| Change from baseline vs placebo, mL | Aclidinium 400 µg | Tiotropium 18 µg | Difference |
|---|---|---|---|
| Normalized FEV1 AUC0–24 | 150† | 140† | 10 |
| Normalized FEV1 AUC12–24 | 160† | 123† | 37 |
| Normalized FEV1 AUC0–12 | 138† | 156† | –18 |
| Morning pre-dose (trough) FEV1 | 141† | 102* | 39 |
| Peak FEV1 | 180† | 172† | 8 |
↵* p<0.05; †p<0.0001.