FEV_{1} (ml) | Placebo | PH-797804 dose | |||
---|---|---|---|---|---|
0.5 mg | 3 mg | 6 mg | 10 mg | ||
N | 42 | 18 | 44 | 65 | 42 |
Raw mean change from baseline | −43 | 18 | 38 | 37 | 4 |
SD of change from baseline | 160 | 128 | 235 | 192 | 201 |
Estimated change from baseline* | −52 | 7 | 34 | 41 | 15 |
95% CrI for change from baseline | (−110 to 6) | (−62 to 82) | (−17 to 86) | (−2 to 85) | (−42 to 73) |
Estimated difference from placebo | 59 | 85 | 92 | 66 | |
95% CrI of effect over placebo | (−23 to 149) | (8 to 164) | (18 to 166) | (−17 to 151) | |
Probability of effect >0 ml† | 0.927 | 0.984 | 0.992 | 0.945 | |
Probability of effect >75 ml ‡ | 0.331 | 0.601 | 0.673 | 0.408 |
*The estimates are derived from the fitted statistical Bayesian model (normal dynamic linear model).
†A value>0.95 indicates statistical significance.
‡A value>0.5 indicates that the magnitude of effect is of interest.
CrI, credible interval (ie, Bayesian CI); FEV_{1}, forced expiratory volume in 1 s.