Relationship between maternal late-pregnancy 25-hydroxyvitamin D status and offspring lung function at 6 years
| Univariable model | Final model | |||||||
| β | (95% CI) | p Value | n | β | 95% CI | p Value | n | |
| FEV1 absolute | −0.0007 | −0.0054 to 0.0039 | 0.76 | 739 | −0.0001 | −0.0046 to 0.0043 | 0.95 | 731 |
| FEV1 z-score | 0.012 | −0.0078 to 0.033 | 0.23 | 739 | 0.011 | −0.0091 to 0.031 | 0.28 | 739 |
| FVC absolute | −0.001 | −0.0068 to 0.0045 | 0.69 | 739 | −0.0001 | −0.0054 to 0.0052 | 0.96 | 730 |
| FVC z-score | 0.013 | −0.010 to 0.036 | 0.27 | 739 | 0.012 | −0.011 to 0.035 | 0.31 | 739 |
| BHR slope | −0.084 | −0.194 to −0.025 | 0.13 | 216 | −0.102 | −0.211 to −0.008 | 0.07 | 208 |
Data presented as change in RR per 10 nmol/litre change in maternal serum 25-hydroxyvitamin D status at 34 weeks' pregnancy.
Adjusted models: FEV1 absolute—child's age at testing, child's gender, parity, maternal BMI, maternal height; FEV1 z-score—child's gender; FVC absolute—child's age at testing, child's gender, age at introduction of solid foods, maternal BMI, maternal height; FVC z-score—child's gender; BHR—maternal age, smoking in pregnancy, paternal eczema, age at introduction of solid foods.
BHR, bronchial hyperresponsiveness; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.