Table 1

Baseline patient characteristics, n=100

% Predicted
Sex, M/F42/58
Age, years65 (8)
BMI, kg/m2 25 (5)
Dyspnea, mMRC*
 Grade 0–116 (16%)
 Grade 249 (50%)
 Grade 317 (17%)
 Grade 416 (16%)
Lung function
 FEV1, litres1.0 (0.4)41.2 (13.1)
 FEV1/FVC0.44 (0.10)
DL,CO, mmol/min/kPa3.2 (1.3)40 (16)
DL,CO/VA, mmol/min/kPa/litre0.7 (0.3)49 (20)
 TLC, litre7.2 (1.7)124 (24)
 RV, litre4.4 (1.4)201 (61)
Blood gases and pulse oximetry at sea level
 PaO2, kPa9.0 (1.1)
 PaCO2, kPa5.0 (0.6)
 SpO2, %93 (3)
Six min walk test
 Distance, m405 (101)
 Exercise SpO2, %83 (6)
 Dyspnoea, Borg CR106.6 (2.0)
HAST blood gases and pulse oximetry
 PaO2, kPa6.3 (0.7)
 PaCO2, kPa4.9 (0.6)
 SaO2, %83 (5)
 SpO2, %83 (4)
  • Data are presented as n (%) and mean (SD).

  • * n=98.

  • BMI, body mass index; DL,CO, diffusing capacity of the lung for carbon monoxide; FEV1%predicted, forced expiratory volume in 1 s in per cent of predicted; FVC, forced vital capacity; HAST, hypoxia-altitude simulation test; mMRC, modified Medical Research Council Dyspnea Scale; PaCO2, arterial carbon dioxide pressure; PaO2, arterial oxygen pressure; RV, residual volume; SaO2, arterial oxygen saturation; SpO2, arterial oxygen saturation by pulse oximetry; TLC, total lung capacity; VA, alveolar volume.