Inflammation and remodelling in biopsies
| Controlled asthma | Uncontrolled asthma | ||
|---|---|---|---|
| Totally controlled (n=19) | Well controlled (n=33) | (n=37) | |
| Inflammatory cells | |||
| Eosinophils | 2 (0–26) | 1 (0–21) | 2 (0–32) |
| Mast cells | 12 (3–24) | 8 (0–26) | 9 (0–17) |
| Macrophages | 15 (0–30) | 12 (0–47) | 11 (0–57) |
| Neutrophils | 9 (0–46) | 5 (0–34) | 6 (0–20) |
| T lymphocytes (CD3+) | 68 (23–294) | 55 (13–177) | 66 (4–219) |
| T lymphocytes (CD4+) | 24 (4–70) | 16 (0–67) | 17 (0–71) |
| T lymphocytes (CD8+) | 25 (4–139) | 17 (0–136) | 23 (1–205) |
| Inflammatory cell activation | |||
| EPX immunopositivity | 157 (16–1268) | 101 (6–1787) | 219 (19–5312)*, ** |
| Mast cell degranulation (%) | 80 (22–100) | 69 (25–100) | 75 (0–100) |
| Remodelling | |||
| BM thickness (µm) | 6.3 (4.3–9) | 5.2 (3.6–8.7) | 5.9 (2.8–12.6) |
| Intact epithelium (%) | 13 (0–32.8) | 10.5 (0–65.3) | 5.6 (0–47.6)* |
Inflammatory cells are expressed as the number per 0.1 mm2. Values are medians (ranges).
*p<0.05 versus controlled, **p<0.01 versus well controlled.
BM, basement membrane; EPX, eosinophil peroxidase.