Median (IQR) BAL cytokines in WT and LTF mice treated with PBS or LPS
| Cytokine (pg/ml) | WT PBS N=7 | LTF PBS N=6 | p Value | WT LPS N=5 | LTF LPS N=6 | p Value |
|---|---|---|---|---|---|---|
| IFN-γ | 0.0 (0.0–0.1) | 0.2 (0.1–0.4) | 0.405 | 3.2 (0.7–17.5) | 96.6 (1.2–222.3) | 0.230 |
| IL-1β | 1.3 (0.6–2.4) | 1.4 (0.4–11.0) | 0.986 | 43.1 (23.7–55.4) | 75.5 (14.1–167.4) | 0.937 |
| IL-10 | 0.3 (0.0–2.1) | 0.1 (0.0–1.9) | 0.961 | 15.0 (8.7–19.1) | 62.8 (45.3–96.3) | 0.034 |
| IL-12 | 0.0 (0.0–1.1) | 0.1 (0.0–1.9) | 0.924 | 23.0 (17.0–36.6) | 148.2 (0.0–354.9) | 0.008 |
| IL-6 | 0.5 (0.0–2.1) | 27.9 (1.0–83.0) | 0.021 | 897.8 (548.5–1124.4) | 2255.1 (845.2–5113.1) | 0.591 |
| IL-8 | 7.7 (3.4–15.1) | 32.9 (13.0–63.4) | 0.012 | 649.3 (522.6–1034.8) | 1704.3 (797.9–2470.9) | 0.464 |
| TNF-α | 0.8 (0.3–1.1) | 1.2 (0.5–1.9) | 0.917 | 170.7 (108.3–544.5) | 985.9 (452.4–2958.7) | 0.027 |
p Values are for comparison of WT versus LTF within each treatment group.
BAL, bronchoalveolar lavage; IFN, interferon; IL, interleukin; LPS, lipopolysaccharide; LTF, low tissue factor; PBS, phosphate-buffered saline; TNF, tumour necrosis factor; WT, wild type.