Table 2

Unadjusted and adjusted means and intervals (5th and 95th percentiles) for α1-antitrypsin (AAT) serum concentration in the six main SERPINA1 genotype classes

SERPINA1 genotypeUnadjusted AAT serum concentrations, N=5981*Adjusted AAT serum concentrations, N=5768
NMean, SD (g/litre)5th percentile95th percentileNMean (g/litre)5th percentile95th percentile
MS4511.085, 0.160.881.374381.0820.9021.312
SS100.849, 0.100.731.06100.8230.7351.009
MZ1430.805, 0.110.661.001360.8110.6721.011
SZ100.555, 0.060.490.6690.5540.4800.638
ZZ10.320, 0.00
  • * Subjects with rare variants (42) and samples with missing AAT levels (34) were excluded.

  • Adjusted for age, sex, area, alcohol consumption (yes/no), systolic blood pressure, body mass index, smoking habit (never, former, current) and C-reactive protein levels.

  • Additionally excluded were subjects with missing covariate data (212) and ZZ genotype due to insufficient frequency (1).