Associations with progression of bronchiectasis
| Clinical factors | Model 1* | Model 2† | ||
| Regression coefficient‡ (95% CI) | p Value | Regression coefficient‡ (95% CI) | p Value | |
| Age | 1.07 (1.00 to 1.14) | 0.041 | 1.06 (1.01 to 1.12) | 0.020 |
| Sex (female) | 1.08 (0.90 to 1.30) | 0.408 | – | – |
| Severe CFTR genotype | 1.54 (1.19 to 1.99) | 0.001 | 1.28 (1.04 to 1.59) | 0.021 |
| Pancreatic sufficiency | 0.81 (0.63 to 1.05) | 0.106 | – | – |
| Respiratory symptoms at the initial scan | 1.13 (0.88 to 1.45) | 0.325 | – | – |
| Respiratory symptoms at the subsequent scan | 1.39 (1.16 to 1.67) | <0.001 | – | – |
| CT factors | ||||
| Detectable air trapping at the initial scan | 1.31 (1.09 to 1.58) | 0.004 | – | – |
| Air trapping extent at the initial scan | 1.05 (1.01 to 1.09) | 0.008 | – | – |
| Detectable air trapping at the subsequent scan | 1.41 (1.12 to 1.77) | 0.004 | – | – |
| Air trapping extent at the subsequent scan | 1.09 (1.05 to 1.13) | <0.001 | – | – |
| Change in air trapping extent | 1.08 (1.05 to 1.12) | <0.001 | – | – |
| Bronchoalveolar lavage factors at the initial scan | ||||
| Uninfected | (Comparator) | (Comparator) | ||
| Mixed oral flora | 0.91 (0.72 to 1.15) | 0.439 | 0.85 (0.67 to 1.10) | 0.218 |
| Infected | 1.16 (0.92 to 1.48) | 0.212 | 1.00 (0.79 to 1.27) | 0.973 |
| Detectable neutrophil elastase | 1.04 (0.84 to 1.30) | 0.692 | – | – |
| Inflammatory response score | 1.07 (1.01 to 1.13) | 0.016 | 1.02 (0.96 to 1.08) | 0.508 |
| Bronchoalveolar lavage factors at the subsequent scan | ||||
| Uninfected | (Comparator) | (Comparator) | ||
| Mixed oral flora | 1.35 (1.08 to 1.68) | 0.008 | 1.23 (0.97 to 1.56) | 0.091 |
| Infected | 1.57 (1.23 to 2.01) | <0.001 | 1.38 (1.07 to 1.79) | 0.014 |
| Detectable neutrophil elastase | 1.44 (1.14 to 1.80) | 0.002 | – | – |
| Inflammatory response score | 1.18 (1.10 to 1.26) | <0.001 | 1.14 (1.08 to 1.22) | <0.001 |
| Change in inflammatory response score | 1.18 (1.11 to 1.26) | <0.001 | – | – |
–Not included in model. Bold, significant p-values (<0.05).
↵* Model 1: Each variable analysed in a separate model after adjusting for age at the initial scan and severe CFTR genotype.
↵† Model 2: Combined model adjusted for age at initial scan, severe CFTR genotype, infection status at the initial and subsequent scans and inflammation status at the initial and subsequent scans.
↵‡ Regression coefficients have been back-transformed from the logarithmic scale.
CFTR, cystic fibrosis transmembrane regulator.